糖尿病患者血糖调节系统的数学建模

Q3 Medicine
V. A. Karpel'ev, Yu. I. Filippov, Y. Tarasov, M. D. Boyarsky, A. Y. Mayorov, M. Shestakova, I. Dedov
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引用次数: 10

摘要

近年来,人们对碳水化合物代谢调节系统的数学建模越来越感兴趣。这与胰岛素泵的“闭环”发展有关(它根据血糖水平控制胰岛素输注)。为了创建一个使用胰岛素泵自动控制胰岛素(和其他激素)输注的算法,有必要准确预测血糖水平。因此,数学建模的首要目的是预测由多种外部因素引起的血糖水平变化。本文综述了血糖水平控制生理系统(简化胰岛素-葡萄糖系统)的主要数学模型。详细描述了两大类模型——经验模型和理论模型。目前还没有理想的碳水化合物代谢调控系统的数学模型。然而,在血糖水平控制建模和模拟领域的成功对于糖尿病预防和治疗技术的进一步发展,特别是创造人工胰腺是必不可少的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Mathematical Modeling of the Blood Glucose Regulation System in Diabetes Mellitus Patients].
Interest in the mathematical modeling of the carbohydrate metabolism regulation system increases in recent years. This is associated with a "closed loop" insulin pump development (it controls an insulin infusion depending on the blood glucose level). To create an algorithm for the automatic control of insulin (and other hormones) infusion using an insulin pump it is necessary to accurately predict glycaemia level. So, the primary objective of mathematical modeling is to predict the blood glucose level changes, caused by the wide range of external factors. This review discusses the main mathematical models of blood glucose level control physiological system (simplified insulin-glucose system). The two major classes of models--empirical and theoretical--are described in detail. The ideal mathematical model of carbohydrate metabolism regulatory system is absent. However, the success in the field of blood glucose level control modeling and simulating is essentialfor the further development of diabetes prevention and treatment technologies, and creating an artificial pancreas in particular.
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CiteScore
1.50
自引率
0.00%
发文量
31
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