注射用磷酸钙骨水泥的最新进展

S. Hablee, N. N. Razali, A. Alqap, I. Sopyan
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引用次数: 5

摘要

近年来,新兴的微创骨移植技术引起了人们对可注射磷酸钙水泥(CPC)作为骨填充材料的兴趣,这种材料能够在体温范围内固定。近年来,开发了多种注射剂CPC配方。可注射型CPC的开发主要集中在获得最佳的凝固时间、力学性能、注射能力和体内性能,使其临床应用于骨科、牙科、颅面颌面、椎体成形术和后凸成形术以及药物输送等领域。现有的注射用CPCs研究考察了液粉比、固液相类型、液相浓度、水泥密度和孔隙度、水泥粉粒度及其结晶度、针状粒径、凝结剂、凝结促进剂和内聚促进剂的使用等因素对水泥的处理、力学和生物学性能的影响。本文综述了近年来可注射性CPC骨填充材料的研究进展。并对与注射用CPC发展有关的一些著名专利进行了综述
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recent Developments on Injectable Calcium Phosphate Bone Cement
New emerging micro-invasive bone grafting techniques have recently risen the interest towards injectable calcium phosphate cement (CPC) as bone filling material that is able to set itself within the body temperature. There are various formulations of injectable CPC that have been developed in recent years. The development of injectable CPC mainly focuses on getting optimum setting times, mechanical properties, injection capabilities and in vivo properties so that the cement is clinically applicable for orthopedic, dental, craniofacial and maxillofacial, vertebroplasty and kyphoplasty, and drug delivery applications. The existing studies on injectable CPCs have investigated the effects of some factors, such as liquid to powder (P/L) ratio, types solid and liquid phase used, concentration of the liquid phase, density and porosity of the cement, particle size of the cement powder and its crystallinity, needle size, and use of setting retardants, setting accelerators and cohesion promoters on the handling, mechanical and biological properties of the cement. The aim of this paper is to review the recent developments of injectable CPC for bone filling materials. Some prominent patents related to the developments of injectable CPC are also reviewed
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