25℃下对乙酰氨基酚在n -甲基-2-吡咯烷酮+乙醇+水混合物中的溶解度预测

Journal of Applied Solution Chemistry and Modeling Pub Date : 2014-09-18 DOI:10.6000/1929-5030.2014.03.03.4

F. Ahmadi, K. Sadrjavadi, G. Mohammadi, Amir Separham, M. Barzegar-Jalali, M. Khoubnasabjafari, A. Jouyban

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引用次数: 0

摘要

用摇瓶法测定了扑热息痛在25 Â℃下n -甲基-2-吡咯烷酮(NMP) +乙醇和NMP +乙醇+水溶剂混合物中的溶解度。生成的数据扩展了药物的溶解度数据库，并用于评估Jouyban-Acree模型在NMP +乙醇+水混合物中的溶解度预测能力。通过预测溶解度与实验溶解度之间的平均百分比偏差(MPD)来评价预测溶解度的准确性。用Jouyban-Acree模型预测扑热息痛在25 Â℃下NMP +乙醇+水混合物中的溶解度的MPD为14.6%。

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Solubility Prediction of Paracetamol in N-Methyl-2-pyrrolidone + Ethanol + Water Mixtures at 25 C

The solubility of paracetamol in N-Methyl-2-pyrrolidone (NMP) + ethanol and NMP + ethanol + water solvent mixtures at 25 Â°C was determined using the shake flask method. The generated data extended the solubility database of pharmaceuticals and also was used to assess the solubility prediction capability of the Jouyban-Acree model in NMP + ethanol + water mixtures. The accuracy of the predicted solubilities was evaluated by the mean percentage deviation (MPD) between the predicted and experimental solubilities. The MPD of the Jouyban-Acree model for predicting the solubility of paracetamol in NMP + ethanol + water mixtures at 25 Â°C was 14.6 %.

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Journal of Applied Solution Chemistry and Modeling

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