S. Mustapha, M. T. Bolori, N. Ajayi, H. Nggada, U. Pindiga, W. Gashau, M. Khalil
{"title":"尼日利亚肝细胞癌患者的丙型肝炎病毒抗体","authors":"S. Mustapha, M. T. Bolori, N. Ajayi, H. Nggada, U. Pindiga, W. Gashau, M. Khalil","doi":"10.5580/1669","DOIUrl":null,"url":null,"abstract":"Objective: The aim of the study is to determine the frequency of antibodies to hepatitis C virus among Nigerian patients with hepatocellular carcinoma. Method: The study was prospective. Patients with histologically confirmed hepatocellular carcinoma were studied. Sera of the patients were tested for hepatitis C virus antibodies using a third generation ELISA. Results: A total of 108 patients consisting of 81 males and 27 females were studied, giving a male to female ratio of 4:1. Their ages ranged from 22 to 75 years with a mean of 48 years (SD±13.0). The highest incidence of hepatocellular carcinoma was found among those aged 4049 years. A total of 19 patients (17.6%) were positive for HCV antibodies. There was no significant difference in the frequencies of these antibodies between the male and female patients. Conclusion: HCV plays a significant role in the etiology of hepatocellular carcinoma in Nigeria. Therefore, patients with chronic hepatitis C should be screened for HCC on regular basis.","PeriodicalId":22534,"journal":{"name":"The Internet Journal of Oncology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2006-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"8","resultStr":"{\"title\":\"Hepatitis C Virus Antibodies In Nigerians With Hepatocellular Carcinoma\",\"authors\":\"S. Mustapha, M. T. Bolori, N. Ajayi, H. Nggada, U. Pindiga, W. Gashau, M. Khalil\",\"doi\":\"10.5580/1669\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: The aim of the study is to determine the frequency of antibodies to hepatitis C virus among Nigerian patients with hepatocellular carcinoma. Method: The study was prospective. Patients with histologically confirmed hepatocellular carcinoma were studied. Sera of the patients were tested for hepatitis C virus antibodies using a third generation ELISA. Results: A total of 108 patients consisting of 81 males and 27 females were studied, giving a male to female ratio of 4:1. Their ages ranged from 22 to 75 years with a mean of 48 years (SD±13.0). The highest incidence of hepatocellular carcinoma was found among those aged 4049 years. A total of 19 patients (17.6%) were positive for HCV antibodies. There was no significant difference in the frequencies of these antibodies between the male and female patients. Conclusion: HCV plays a significant role in the etiology of hepatocellular carcinoma in Nigeria. Therefore, patients with chronic hepatitis C should be screened for HCC on regular basis.\",\"PeriodicalId\":22534,\"journal\":{\"name\":\"The Internet Journal of Oncology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2006-12-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Internet Journal of Oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5580/1669\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Internet Journal of Oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5580/1669","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Hepatitis C Virus Antibodies In Nigerians With Hepatocellular Carcinoma
Objective: The aim of the study is to determine the frequency of antibodies to hepatitis C virus among Nigerian patients with hepatocellular carcinoma. Method: The study was prospective. Patients with histologically confirmed hepatocellular carcinoma were studied. Sera of the patients were tested for hepatitis C virus antibodies using a third generation ELISA. Results: A total of 108 patients consisting of 81 males and 27 females were studied, giving a male to female ratio of 4:1. Their ages ranged from 22 to 75 years with a mean of 48 years (SD±13.0). The highest incidence of hepatocellular carcinoma was found among those aged 4049 years. A total of 19 patients (17.6%) were positive for HCV antibodies. There was no significant difference in the frequencies of these antibodies between the male and female patients. Conclusion: HCV plays a significant role in the etiology of hepatocellular carcinoma in Nigeria. Therefore, patients with chronic hepatitis C should be screened for HCC on regular basis.
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