甲醇、乙醇和丙酮对黄芪总酚类物质和抗氧化剂的比较研究及其抗炎活性评价

Iqra Arshad, Muhammad Ayub Kakar, A. Kakar, N. Kakar, Saeeda Khanam, Rehana Kamal, A. Muhammad
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引用次数: 0

摘要

黄芪(Astragalus Stocksii)是一种产于巴基斯坦奎达哈纳山谷的开花植物,多年来一直被用作家庭药用植物。它是一种令人鼓舞的生物活性化合物来源,并已按惯例对几种疾病进行了处理。本研究采用丙酮、乙醇和甲醇三种不同的溶剂对黄芪的酚类物质、抗氧化剂和抗炎活性进行了评价。结果表明,萃取率与萃取溶剂的种类有关。其中,甲醇提取液的酚类物质含量最高(10.086±0.08mgCE/g DW),总抗氧化能力最高(TAC,磷酸- molibdenum法IC50=14.50±0.01 μg/mL, DPPH法IC50=66.62±0.03 μg/mL),抗炎活性最高(氧化爆发法IC50=75.0±2.5 μg/mL)。结果表明,甲醇是提取黄芪中酚类物质和抗氧化剂的最佳溶剂。黄芪具有较高的抗炎效果,可用于制药和营养保健行业。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparative Study of Total Phenolics and Antioxidants in ASTRAGLUS STOCKSII by using Methanol, Ethanol and Acetone and to Evaluate its Anti -Inflammatory Activity
Astragalus Stocksii a local flowering plant found in Hana Valley, Quetta Pakistan, used as home medicinal plant form many years. It is an encouraging source of bioactive compounds and has been conventionally manipulated for the coverage of several diseases. The present study based on the evaluation of phenolics, antioxidants and anti-inflammatory activities of Astragalus Stocksii by using three different solvents, i.e. ;acetone, ethanol and methanol. The results showed that extraction yield depends upon the type of the solvents used for extraction. Among these, extraction in methanol has the highest phenolic contents (10.086±0.08mgCE/g DW),total antioxidant capacity (TAC, IC50=14.50±0.01 μg/mL,phospho-molibdenummethod,IC50=66.62± 0.03 μg/mL by DPPH method)and high anti-inflammatory activity (IC50=75.0 ±2.5 μg/mL, oxidative burst assay). These results indicate that methanol is the best solvent for extraction of phenolic and antioxidants in Astragalus Stocksii. The high results of anti-inflammatory for Astragalus Stocksii suggests its use inpharmaceutical and nutraceutical industries.
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