中毒性表皮坏死松解患者血浆置换。

Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis Pub Date : 2002-06-01 DOI:10.1046/J.1526-0968.2002.00409.X

G. Bamichas, T. Natse, Fotini Christidou, Maria Stangou, A. Karagianni, S. Koukourikos, G. Chaidemenos, F. Chrysomallis, Kostas Sombolos

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引用次数: 75

摘要

我们描述了我们对13例药物性中毒性表皮坏死松解(TEN)患者进行血浆置换(PE)治疗的经验，其中4例患有恶性疾病。皮肤病变占体表总面积的17% ~ 100%，累及1 ~ 4个粘膜。这些病人都没有住进烧伤科。患者接受了2 - 5次PE治疗(平均3.4 +/- 0.2标准差，中位数3)，交换6.6 - 17.6 L血浆(平均10.1 +/- 0.7标准差，中位数10)。8例患者每隔一天进行体育锻炼，5例患者每天进行体育锻炼。死亡3例(23%)，痊愈10例(77%)。血浆置换可能是一种有效的治疗方法，在烧伤病房外住院的药物性TEN患者。

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Plasma exchange in patients with toxic epidermal necrolysis.

We describe our experience with plasma exchange (PE) therapy in 13 patients with drug-induced toxic epidermal necrolysis (TEN), 4 of whom had malignant disorders. Skin lesions covered 17% to 100% of total body surface area and 1 to 4 mucous membranes were involved. None of the patients was hospitalized in a burn unit. The patients underwent from 2 to 5 PE sessions (mean 3.4 +/- 0.2 standard error of mean [SEM], median 3) exchanging 6.6 to 17.6 L of plasma (mean 10.1 +/- 0.7 SEM, median 10). PE sessions were carried out every other day in 8 patients and daily in 5. Three patients died (23%) while the remaining 10 (77%) had a full recovery. Plasmapheresis may be an effective treatment in patients with drug-induced TEN hospitalized outside a burn unit.

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Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis

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