壳三酸苷酶的免疫调节作用

Q2 Biochemistry, Genetics and Molecular Biology

Enzyme Research Pub Date : 2016-01-03 DOI:10.1155/2016/2682680

M. A. Elmonem, L. P. Van den Heuvel, E. Levtchenko

{"title":"壳三酸苷酶的免疫调节作用","authors":"M. A. Elmonem, L. P. Van den Heuvel, E. Levtchenko","doi":"10.1155/2016/2682680","DOIUrl":null,"url":null,"abstract":"Chitotriosidase enzyme (EC: 3.2.1.14) is the major active chitinase in the human body. It is produced mainly by activated macrophages, in which its expression is regulated by multiple intrinsic and extrinsic signals. Chitotriosidase was confirmed as essential element in the innate immunity against chitin containing organisms such as fungi and protozoa; however, its immunomodulatory effects extend far beyond innate immunity. In the current review, we will try to explore the expanding spectrum of immunological roles played by chitotriosidase enzyme in human health and disease and will discuss its up-to-date clinical value.","PeriodicalId":11835,"journal":{"name":"Enzyme Research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"51","resultStr":"{\"title\":\"Immunomodulatory Effects of Chitotriosidase Enzyme\",\"authors\":\"M. A. Elmonem, L. P. Van den Heuvel, E. Levtchenko\",\"doi\":\"10.1155/2016/2682680\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Chitotriosidase enzyme (EC: 3.2.1.14) is the major active chitinase in the human body. It is produced mainly by activated macrophages, in which its expression is regulated by multiple intrinsic and extrinsic signals. Chitotriosidase was confirmed as essential element in the innate immunity against chitin containing organisms such as fungi and protozoa; however, its immunomodulatory effects extend far beyond innate immunity. In the current review, we will try to explore the expanding spectrum of immunological roles played by chitotriosidase enzyme in human health and disease and will discuss its up-to-date clinical value.\",\"PeriodicalId\":11835,\"journal\":{\"name\":\"Enzyme Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-01-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"51\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Enzyme Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/2016/2682680\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Enzyme Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2016/2682680","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}

引用次数: 51

摘要

壳三酸苷酶(EC: 3.2.1.14)是人体内主要的几丁质酶。它主要由活化的巨噬细胞产生，其表达受多种内源性和外源性信号调节。壳三醇苷酶被证实是抵抗含几丁质生物(如真菌和原生动物)先天免疫的必需元素;然而，其免疫调节作用远远超出了先天免疫。在这篇综述中，我们将尝试探索壳三酸苷酶在人类健康和疾病中所起的免疫学作用的扩展谱，并将讨论其最新的临床价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Immunomodulatory Effects of Chitotriosidase Enzyme

Chitotriosidase enzyme (EC: 3.2.1.14) is the major active chitinase in the human body. It is produced mainly by activated macrophages, in which its expression is regulated by multiple intrinsic and extrinsic signals. Chitotriosidase was confirmed as essential element in the innate immunity against chitin containing organisms such as fungi and protozoa; however, its immunomodulatory effects extend far beyond innate immunity. In the current review, we will try to explore the expanding spectrum of immunological roles played by chitotriosidase enzyme in human health and disease and will discuss its up-to-date clinical value.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Enzyme Research Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

4.60

自引率

0.00%

发文量