STUDY ON THE ASSOCIATION BETWEEN ACE GENE POLYMORPHISMS WITH ESSENTIAL HYPERTENSION AND INSULIN RESISTANCE

Objective:To explore the association of ACE gene polymorphisms with essential hypertension and insulin resistance in Chinese population.Mothod:A population-base case-control study was carried out.Possible factors related to essential hypertension were inquired in 112 essential hypertensive patients and the same amount of sex age-matched healthy control subjects.Their fasting blood sugar,fasting blood insulin were measured.ACE gene polymorphisms were measured by using PCR method.Result:The genotype composition of ACE(I/D) polymorphisms had significant difference between the case group and the control group.Genotype DD in the case group was higher than in the control group,espically for males case group.Compare with non-obesity subjects whose ACE genotype is DD,non-obesity subjects with genotype Ⅱ,especially for males,had a higher ISI value.Conclusion:The results suggest that genetic varitaion in the ACE gene may be associated with essential hypertension and insulin resistance in Chinese population.The genotype DD of ACE gene may be an independent predictor of essential hypertension,espically for men;and it could be a genetic linkage of essential hypertension.The non-obosity subjects with genotype Ⅱ of ACE gene,males in particular,are liable to insulin resistance.