ace基因多态性与原发性高血压和胰岛素抵抗的关系研究

中国医师进修杂志 Pub Date : 2000-07-15 DOI:10.3760/CMA.J.ISSN.1673-4904.2000.07.009

Y. Zhan, W. Qian, Hai-yan Wang

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引用次数: 0

摘要

目的:探讨ACE基因多态性与中国人群原发性高血压和胰岛素抵抗的关系。方法:采用人群为基础的病例对照研究。对112例原发性高血压患者和同等数量的性别、年龄匹配的健康对照者进行高血压相关因素调查。测量了他们的空腹血糖和空腹胰岛素。采用PCR法检测ACE基因多态性。结果:病例组与对照组ACE(I/D)多态性基因型组成差异有统计学意义。病例组DD基因型高于对照组，尤其是男性病例组。与ACE基因型为DD的非肥胖受试者相比，基因型为Ⅱ的非肥胖受试者，尤其是男性的ISI值更高。结论:ACE基因的遗传变异可能与中国人群原发性高血压和胰岛素抵抗有关。ACE基因的DD基因型可能是原发性高血压的独立预测因子，特别是对于男性，它可能是原发性高血压的遗传连锁。具有ACE基因Ⅱ型的非肥胖受试者，尤其是男性，易发生胰岛素抵抗。

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STUDY ON THE ASSOCIATION BETWEEN ACE GENE POLYMORPHISMS WITH ESSENTIAL HYPERTENSION AND INSULIN RESISTANCE

Objective:To explore the association of ACE gene polymorphisms with essential hypertension and insulin resistance in Chinese population.Mothod:A population-base case-control study was carried out.Possible factors related to essential hypertension were inquired in 112 essential hypertensive patients and the same amount of sex age-matched healthy control subjects.Their fasting blood sugar,fasting blood insulin were measured.ACE gene polymorphisms were measured by using PCR method.Result:The genotype composition of ACE(I/D) polymorphisms had significant difference between the case group and the control group.Genotype DD in the case group was higher than in the control group,espically for males case group.Compare with non-obesity subjects whose ACE genotype is DD,non-obesity subjects with genotype Ⅱ,especially for males,had a higher ISI value.Conclusion:The results suggest that genetic varitaion in the ACE gene may be associated with essential hypertension and insulin resistance in Chinese population.The genotype DD of ACE gene may be an independent predictor of essential hypertension,espically for men;and it could be a genetic linkage of essential hypertension.The non-obosity subjects with genotype Ⅱ of ACE gene,males in particular,are liable to insulin resistance.

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来源期刊

中国医师进修杂志

自引率

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发文量

26239

期刊介绍： Chinese Journal of Postgraduates of Medicine (founded in 1978, monthly) is one of the series of journals of the Chinese Medical Association (CMA) under the supervision of the National Health Commission of the People's Republic of China, sponsored by the Chinese Medical Association (CMA) and Dalian Institute of Theoretical Medicine (DITM). It is a core journal of Chinese science and technology, a statistical source journal of Chinese scientific and technical papers, and a statistical source journal of China Academic Journal Impact Factor Annual Report. The journal adheres to the purpose of using continuing medical education and post training, highlights new theories, new knowledge, new methods and new technologies, and focuses on the combination of theory and practice, and the combination of popularisation and improvement. Main columns: Special tutorials, expert forums, clinical treatises, clinical experience, reviews and lectures, continuing medical education, teaching and research, advanced training forum, drugs and clinics, overview of progress, introduction of new technologies, imaging and clinics, lessons learnt, discussions and evaluations, case reports, discussions of clinical cases, conference proceedings, and domestic and international academic developments. The main target readers are clinical medical personnel in internal medicine, surgery, gynaecology, paediatrics and ophthalmology.