静脉激光血液照射纠正手术窘迫引起的过氧化和抗氧化活性的潜力

L. V. Musikhin, V. S. Shiryaev, F. M. Shvetsky, V. Potievskaya, M. B. Potievsky, D. S. Gorin, O. I. Bugrovskaya, A. Khosrovyan
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引用次数: 0

摘要

目的:探讨胆囊手术干预过程中静脉低水平激光血液照射(ILBI)的保护作用,并研究其抗氧化活性、脂质过氧化和内源性中毒状况。材料和方法。在围手术期,主组(I) 40例患者采用传统治疗方法,包括药物制剂和静脉激光血液照射。对照组(II) 45例患者仅接受传统(药物治疗)治疗。两组手术期间的麻醉保护均为经典的神经轻镇痛。两组患者年龄无明显差异。采用氦氖激光“Atoll”632 nm (Fokon Ltd, St-Petersburg, Russia)进行静脉激光血液照射。手术期间,在不同的手术阶段进行三次辐射,辐射功率为20 mW,照射时间为15分钟:麻醉诱导前30分钟,创伤期和预期手术结束前30分钟。应用电子顺磁共振技术测定血浆铜蓝蛋白和转铁蛋白水平。建立了表征抗氧化活性水平的铜蓝蛋白/转铁蛋白比值。使用先前发表的技术评估内源性中毒水平。内源性中毒的定量特征是与高分子量组分和低分子量组分相关的光密度值(D280)和总光密度值。患者的ILBI疗程可以中和血液中铜蓝蛋白和转铁蛋白水平的变化。这些数据也证实了ILBI对sh蛋白群的保护作用,或激活因手术攻击和创伤而被氧化损伤的sh蛋白群的恢复。在术前标准治疗的基础上,静脉激光血液照射的保护作用,在现有的传统联合全身麻醉方案下,优化了术中药物麻醉保护。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Potentials of intravenous laser blood irradiation to correct peroxidation and antioxidant activity as a result of surgical distress
Purpose: to reveal protective effects of intravenous low-level laser blood irradiation (ILBI) during surgical interventions at the gallbladder as well as to study the state of antioxidant activity, lipid peroxidation and endogenous intoxication.Material and methods. In the perioperative period, 40 patients from the main group (I) had traditional treatment which included pharmacological preparations and sessions of intravenous laser blood irradiation. 45 patients from the control group (II) had only traditional (pharmacotherapeutic) treatment. In both groups during surgery, the anesthetic protection consisted of classical neuroleptanalgesia. The age of patients in both groups did not differ significantly. Intravenous laser blood irradiation was done with helium-neon laser “Atoll” 632 nm (Fokon Ltd, St-Petersburg, Russia). During surgery, three irradiation sessions were performed at radiation power of 20 mW and exposure 15 minutes at various stages of surgery: 30 minutes before induction of anesthesia, at the traumatic stage and 30 minutes before the expected finish of the surgery. Ceruloplasmin and transferrin levels in the blood plasma were assessed with the electron paramagnetic resonance technique. The ratio of ceruloplasmin/transferrin which characterizes the level of antioxidant activity was also established. The level of endogenous intoxication was assessed using the previously published technique. The quantitative characteristics of endogenous intoxication by this technique is the value of optical density (D280) and total optical density of components related to high molecular weight and low molecular weight fractions.Results. ILBI sessions in patients neutralize changes in the level of ceruloplasmin and transferrin in blood. The data obtained also confirm ILBI protective effects at protein SH-groups or activation of the restoration of protein SH-groups that were damaged by oxidation as a result of surgical aggression and trauma.Conclusion. The protective effect of intravenous laser blood irradiation in addition to the standard preoperative therapy optimizes pharmacological anesthetic protection during surgery under the existing traditional schemes of combined general anesthesia.
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期刊介绍: The main columns of "Chinese Journal of Laser Medicine & Surgery" include treatises, which report the latest research results in basic research and clinical trials in the field of laser medicine; comprehensive reviews of the latest research progress in laser medicine at home and abroad. In addition, there are short reports and excerpts from foreign journals, conference news and other columns. The journal has published a large number of papers on basic research on laser medicine and applied research in various clinical subjects, aiming to play a positive role in promoting the application of laser in medicine and improving the level of laser medicine research.
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