非选择性β受体阻滞剂在等待肝移植的腹水患者食管静脉曲张出血的初级预防中的作用

V. L. Korobka, V. Pasechnikov, R. V. Korobka, E. Pak, A. M. Shapovalov, D. Pasechnikov
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引用次数: 0

摘要

目的:确定非选择性β受体阻滞剂(NSBBs)在食管静脉曲张出血一级预防中的疗效,并评估其对肝移植等待名单(LTWL)中腹水患者生存的影响。材料和方法。我们对肝硬化合并严重腹水和食管静脉曲张且未出血的患者进行了回顾性比较研究。静脉曲张出血的初级预防包括使用nsbb (n = 97,组1),其他患者未使用这些药物(n = 91,组2)。两组之间在临床、实验室和人口学参数、MELD评分和child - turcote - pugh (CTP)肝硬化分级方面无显著差异。纳入研究的患者组在中、大静脉曲张发生率和严重腹水发生率方面无显著差异。NSBBs组出血发生率显著低于非NSBBs组(分别为52.6%和95.6%,p = 0.0001)。nsbs是食管静脉曲张出血初级预防的有效治疗方法,可以挽救生命,防止腹水患者从LTWL中除名。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nonselective beta-blockers in primary prophylaxis of esophageal variceal bleeding in patients with ascites waitlisted for liver transplantation
Objective: to determine the efficacy of non-selective beta-blockers (NSBBs) in the primary prevention of bleeding esophageal varices and to assess their impact on the survival of patients with ascites enrolled in the liver transplant waiting list (LTWL).Materials and methods. We carried out a retrospective comparative study of cirrhotic patients with severe ascites and esophageal varices without bleeding before enrollment in the LTWL. Primary prophylaxis of variceal bleeding included the use of NSBBs (n = 97, group 1). These drugs were not used in the other patients (n = 91, group 2).Results. There were no significant differences between the groups in terms of clinical, laboratory and demographic parameters, MELD scores and Child-Turcotte-Pugh (CTP) classes for cirrhosis. Patient groups included in the study had no significant differences with respect to incidence of medium- and large-sized varices and incidence of severe ascites. Bleeding incidence was significantly lower in the NSBBs group than in the non-NSBBs group (52.6% and 95.6%, respectively, p = 0.0001).Conclusion. NSBBs constitute an efficacious therapy in primary prophylaxis of esophageal variceal bleeding, thereby saving life and preventing delisting of patients with ascites from the LTWL.
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