白刺化学成分对三阴性乳腺癌的体外抗癌活性及基质金属蛋白酶-1抑制作用的研究

Q1 Earth and Planetary Sciences

Indonesian Journal of Science and Technology Pub Date : 2022-05-09 DOI:10.17509/ijost.v7i2.50547

W. Wahyuni, Ajeng Diantini, M. Ghozali, A. Subarnas, E. Julaeha, Riezki Amalia, A. Fristiohady, A. Sundowo, S. Fajriah, Y. E. Hadisaputri, R. M. Febrianti, Fauzia Azzahra, A. W. Yodha, I. Sahidin

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引用次数: 1

摘要

白叶仙花(EA)是苏拉威西岛的特有植物之一。我们测定了从EA根茎提取物中分离得到的细胞毒和抗转移活性。1,7-二苯基-6-庚烯-3- 1、西汀酮、二乙酸新萘醇和乙酸新萘醇的IC50值为134.59;170;128.11;和161.96 μg/mL。化合物还具有抗迁移活性。200-μg/mL sitonon的迁移率最低，为3.32%。辛顿酮、1,7-二苯基-6-庚烯-3- 1、乙酸新萘醇和二乙酸新萘醇的自由键能均为-11.81;-8.25;-6.64;和-6.28 kcal/mol。所有化合物均具有稳定基质金属蛋白酶1复合物的作用。从EA根茎中分离出的分离物具有开发抗三阴性乳腺癌转移的潜力。

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In-Vitro Anticancer Activity of Chemical Constituents from Etlingera alba Poulsen against Triple Negative Breast Cancer and in silico Approaches towards Matrix metalloproteinase-1 Inhibition

Etlingera alba (EA) is one of the endemic plants grown in Sulawesi. We determined the cytotoxic and anti-metastatic activity of isolates obtained from EA rhizome extract. IC50 value for 1,7-diphenyl-6-heptene-3-one, sitostenone, sinapyl alcohol diacetate, and sinapyl alcohol acetate were 134.59; 170 ; 128.11; and 161.96 μg/mL, respectively. The compounds also had anti-migration activity. 200-μg/mL Sitostenon exhibited the lowest migration rate (3.32%). The free bond energies of sitostenon, 1,7-diphenyl-6-heptene-3-one, sinapyl alcohol acetate, and sinapyl alcohol diacetate were -11.81; -8.25; -6.64; and -6.28 kcal/mol, respectively. All compounds were more effective in stabilizing the Matrix metalloproteinase 1 complex. Isolation from EA rhizomes have the potential to be developed as anti-metastatic for Triple-Negative Breast Cancer.

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来源期刊

Indonesian Journal of Science and Technology Engineering-Engineering (all)

CiteScore

11.20

自引率

0.00%

发文量

审稿时长

16 weeks