利用独立成分评估基因组相似性

Q4 Medicine

Revista Brasileira de Biometria Pub Date : 2020-03-29 DOI:10.28951/rbb.v38i1.439

T. Sáfadi, L. M. Ferreira

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引用次数: 0

摘要

我们建议使用独立成分分析来发现基因组的相似性。考虑不同数量的独立成分，采用完全链接法根据混合矩阵的估计系数进行群体识别。分析的序列与结核分枝杆菌基因组菌株相对应，分析了10个序列，这些序列来自国家生物技术信息中心(NCBI, 2017)。每个序列的gc含量使用10,000个碱基的滑动窗口进行评估。利用所分析序列的独立分量进行聚类分析是验证序列相似性的必要手段。

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EVALUATION OF GENOME SIMILARITIES USING INDEPENDENT COMPONENTS

We propose the use of independent component analysis to find similarities of genomes. Considering different numbers of independent components, the complete linkage method was used to identify groups based on the estimated coefficients of the mixing matrix. The sequences analyzed correspond to the strains of the Mycobacterium tuberculosis genome, ten sequences were analyzed, obtained from the National Center for Biotechnology Information (NCBI, 2017). The GC-content of each sequence was evaluated using a sliding window of 10,000 bases. The clustering analysis using the independent components of the analyzed sequences was essential to verify the dissimilarity of the sequences.

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来源期刊

Revista Brasileira de Biometria Agricultural and Biological Sciences-Agricultural and Biological Sciences (all)

自引率

0.00%

发文量

审稿时长

53 weeks