Rituparna Sarma, Ankit Verma, Hasnahana Chetia, Dhirendra K. Sharma
{"title":"热带Silurana tropicalis Gray, 1864","authors":"Rituparna Sarma, Ankit Verma, Hasnahana Chetia, Dhirendra K. Sharma","doi":"10.1016/j.jopr.2013.08.019","DOIUrl":null,"url":null,"abstract":"<div><h3>Aim</h3><p>The objective of the investigation was to predict the three dimensional structure of ageing related proteins of <em>Silurana tropicalis</em> Gray 1864.</p></div><div><h3>Methods</h3><p>The protein sequences were collected from UniProt. Homology modeling of protein structures was generated in SWISS-MODEL workplace. The structures were assessed by ERRAT and RAMPAGE.</p></div><div><h3>Results</h3><p>In <em>S. tropicalis</em> Gray 1864, ageing related total 5 proteins sequences namely prohibitin-2 (301 aa), serum response factor-binding protein 1 (535 aa), reactive oxygen species modulator 1 (79 aa), CDGSH iron-sulfur domain-containing protein 2 (135 aa) and an uncharacterized protein (668 aa) were found (UniProt). SWISS-MODEL workspace generated reliable 3D structures of only two proteins prohibitin-2 (301 aa) and CDGSH iron-sulfur domain-containing protein 2 (135 aa), while it failed to give proper structures for other proteins due to lack of templates. In ERRAT assessment, prohibiin-2 and CDGSH iron-sulfur domain-containing protein 2 scored 51.82% and 97.48% respectively. While in RAMPAGE, prohibitin 2 and CDGSH iron-sulfur domain-containing protein 2 scored 90.7% and 97.7% respectively.</p></div><div><h3>Conclusion</h3><p>The present study demonstrated the 3D structures of prohibitin-2 and CDGSH iron-sulfur domain-containing protein 2.</p></div>","PeriodicalId":16787,"journal":{"name":"Journal of Pharmacy Research","volume":"7 8","pages":"Pages 762-765"},"PeriodicalIF":0.0000,"publicationDate":"2013-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jopr.2013.08.019","citationCount":"1","resultStr":"{\"title\":\"3D structure prediction of aging related proteins of Silurana tropicalis Gray, 1864\",\"authors\":\"Rituparna Sarma, Ankit Verma, Hasnahana Chetia, Dhirendra K. Sharma\",\"doi\":\"10.1016/j.jopr.2013.08.019\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Aim</h3><p>The objective of the investigation was to predict the three dimensional structure of ageing related proteins of <em>Silurana tropicalis</em> Gray 1864.</p></div><div><h3>Methods</h3><p>The protein sequences were collected from UniProt. Homology modeling of protein structures was generated in SWISS-MODEL workplace. The structures were assessed by ERRAT and RAMPAGE.</p></div><div><h3>Results</h3><p>In <em>S. tropicalis</em> Gray 1864, ageing related total 5 proteins sequences namely prohibitin-2 (301 aa), serum response factor-binding protein 1 (535 aa), reactive oxygen species modulator 1 (79 aa), CDGSH iron-sulfur domain-containing protein 2 (135 aa) and an uncharacterized protein (668 aa) were found (UniProt). SWISS-MODEL workspace generated reliable 3D structures of only two proteins prohibitin-2 (301 aa) and CDGSH iron-sulfur domain-containing protein 2 (135 aa), while it failed to give proper structures for other proteins due to lack of templates. In ERRAT assessment, prohibiin-2 and CDGSH iron-sulfur domain-containing protein 2 scored 51.82% and 97.48% respectively. While in RAMPAGE, prohibitin 2 and CDGSH iron-sulfur domain-containing protein 2 scored 90.7% and 97.7% respectively.</p></div><div><h3>Conclusion</h3><p>The present study demonstrated the 3D structures of prohibitin-2 and CDGSH iron-sulfur domain-containing protein 2.</p></div>\",\"PeriodicalId\":16787,\"journal\":{\"name\":\"Journal of Pharmacy Research\",\"volume\":\"7 8\",\"pages\":\"Pages 762-765\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.jopr.2013.08.019\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pharmacy Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0974694313003411\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmacy Research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0974694313003411","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
3D structure prediction of aging related proteins of Silurana tropicalis Gray, 1864
Aim
The objective of the investigation was to predict the three dimensional structure of ageing related proteins of Silurana tropicalis Gray 1864.
Methods
The protein sequences were collected from UniProt. Homology modeling of protein structures was generated in SWISS-MODEL workplace. The structures were assessed by ERRAT and RAMPAGE.
Results
In S. tropicalis Gray 1864, ageing related total 5 proteins sequences namely prohibitin-2 (301 aa), serum response factor-binding protein 1 (535 aa), reactive oxygen species modulator 1 (79 aa), CDGSH iron-sulfur domain-containing protein 2 (135 aa) and an uncharacterized protein (668 aa) were found (UniProt). SWISS-MODEL workspace generated reliable 3D structures of only two proteins prohibitin-2 (301 aa) and CDGSH iron-sulfur domain-containing protein 2 (135 aa), while it failed to give proper structures for other proteins due to lack of templates. In ERRAT assessment, prohibiin-2 and CDGSH iron-sulfur domain-containing protein 2 scored 51.82% and 97.48% respectively. While in RAMPAGE, prohibitin 2 and CDGSH iron-sulfur domain-containing protein 2 scored 90.7% and 97.7% respectively.
Conclusion
The present study demonstrated the 3D structures of prohibitin-2 and CDGSH iron-sulfur domain-containing protein 2.
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