C. Teixeira, Nuno F S Pinto, David M. Pereira, R. Pereira, M. J. Fernandes, E. M. Castanheira, A. Fortes, M. S. Gonçalves
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Cytotoxicity Studies of Eugenol Amino Alcohols Derivatives
: Eugenol is a phenylpropanoid displaying a wide range of biological activities. In this study, the cytotoxic activity of various β -amino alcohols derivatives from eugenol was evaluated in AGS (gastric cancer) and A549 (lung cancer) cell lines. The results show that some structural modi-fications resulted in enhanced cytotoxic activity towards cancer cells. In addition, the activation of caspase-3 and hence apoptosis induced by these molecules, was also explored. Considering the ob-tained results, some structure/activity relationships can be drawn, which may guide future structural improvements for anticancer agents.
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