A. Abdel-Aziz, N. Elwan, Mona Abdel-Motagaly, S. Nasr, M. Ghareeb
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引用次数: 4
摘要
从芦笋花中分离到一种新的甾体皂苷，命名为(25R)-6α-[(β-D-glucopyranosyl) oxy]-5α-spirostan3β-yl β-D-glucopyranosyl(1′→3′)- o - β-D-glucopyranosyl(2)。此外，还首次从该属植物中分离到一种甾体皂苷(1)、一种黄酮类化合物(3)和一种三萜皂苷(4)，并根据其色谱性质、化学和光谱数据(HR-ESI-MS、H、C NMR、H-H COSY、HSQC和HMBC)进行了鉴定。对这四种化合物的抗菌、抗真菌和抗病毒活性进行了评价。所有化合物对vero细胞株的最大无毒浓度(MNTC)为1.56 μg/mL。化合物1和3的抗病毒活性分别为34.3%和25%。
Phytochemical investigation and differential effects of Cestrum elegans isolated compounds as antimicrobial and virucidal against hepatitis A virus
A new steroidal saponin, named as (25R)-6α-[(β-D-glucopyranosyl) oxy]-5α-spirostan3β-yl β-D-glucopyranosyl (1''→3')-O-β-D-glucopyranosid (2) was isolated from the flowers of Cestrum elegans. In addition, a known steroidal saponin (1), a flavonoid compound (3) along with a triterpene saponin (4) were isolated for the first time in genus Cestrum and identified based on their chromatographic properties, chemical and spectral data (HR-ESI-MS, H, C NMR, H-H COSY, HSQC, and HMBC). The four compounds were evaluated for their antibacterial, antifungal and antiviral activities. The maximum non-toxic concentration (MNTC) on vero cell line was 1.56 μg/mL for all compounds. While, compound 1 and 3 showed antiviral activity of 34.3% and 25%, respectively.
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