乳腺叶状肿瘤中产生的上皮癌:其组织病理学、病理生理学和分子特征的综述。

IF 3.5 4区 医学 Q3 CELL BIOLOGY
Pathobiology Pub Date : 2024-01-01 Epub Date: 2023-11-11 DOI:10.1159/000533745
William Cook, Cheok Soon Lee, Puay Hoon Tan
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引用次数: 0

摘要

上皮细胞增生是叶状瘤(PT)的共同特征,但上皮恶性肿瘤是罕见的。本综述旨在通过分析文献中先前报道的病例的组织病理学和分子特征,进一步了解叶状肿瘤内的上皮恶性肿瘤。PubMed检索了叶状肿瘤内原位癌和浸润性癌的病例报告、病例系列和文献综述。仅包括癌位于PT内的病例。排除同侧或对侧乳房同步癌的病例。我们发现了86例原位癌或浸润性癌。在不同级别的叶状肿瘤中,浸润性癌与原位病变的比例相似。恶性间质与上皮恶性肿瘤的可能性较高相关,分子研究支持可能的因果病理生理关系。与良性肿瘤相比,恶性叶状瘤似乎更有可能包含原位或侵袭性上皮恶性肿瘤。这种较高的可能性表明,恶性间质和转化上皮之间的相互作用可能在这一现象中起着重要作用,但仍有待阐明。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epithelial Carcinomas Arising within Phyllodes Tumours of the Breast: A Review of Their Pathological Characteristics.

Epithelial proliferation is a common feature of phyllodes tumours (PTs), but epithelial malignancy is rare. This review seeks to further our understanding of epithelial malignancy within PTs by analysing their histopathological characteristics in previously reported cases and providing an overview of studies on their pathological features. PubMed and DeepDyve were searched for case reports, case series, and literature reviews of in situ and invasive carcinoma within PTs. Only cases where the carcinoma was within the PT were included. Cases of synchronous carcinoma in the ipsilateral or contralateral breast were excluded. Ninety-eight cases of in situ or invasive carcinoma within a PT were identified. Across the grades of PTs, there was a similar proportion of invasive carcinomas compared to in situ lesions. Malignant PT correlates with a higher likelihood of epithelial malignancy, and molecular studies support a possible causal pathophysiological relationship. This higher likelihood may suggest interactions between malignant stroma and the transforming epithelium that could potentially play a significant role in the phenomenon, which remains to be elucidated. Encasement within a PT likely improves the prognosis of breast carcinoma due to earlier detection. The presence of carcinoma within a malignant PT has uncertain prognostic implications. Thorough sampling of all PTs is recommended for appropriate prognostication and management.

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来源期刊
Pathobiology
Pathobiology 医学-病理学
CiteScore
8.50
自引率
0.00%
发文量
47
审稿时长
>12 weeks
期刊介绍: ''Pathobiology'' offers a valuable platform for the publication of high-quality original research into the mechanisms underlying human disease. Aiming to serve as a bridge between basic biomedical research and clinical medicine, the journal welcomes articles from scientific areas such as pathology, oncology, anatomy, virology, internal medicine, surgery, cell and molecular biology, and immunology. Published bimonthly, ''Pathobiology'' features original research papers and reviews on translational research. The journal offers the possibility to publish proceedings of meetings dedicated to one particular topic.
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