伤口愈合的原理

J. K. Ho, B. Hantash
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引用次数: 4

摘要

伤口愈合是一个不断变化的领域,通过基础科学研究对其机制有了新的认识,从而推动了新疗法的发展。在本文中,我们介绍了目前伤口愈合和瘢痕形成的三个阶段的分子模型:炎症、增殖和重塑。新的细胞信号传导途径,如通过转化生长因子- β和整合素途径的机械转导,为伤口治疗开辟了各种靶点。其他治疗方法,如负压装置和抗微生物肽,随着更多数据的可用性正在得到改进。像Regranex这样的基因治疗的前沿疗法正在进行大量的研究,还有各种分子机制仍有待阐明的治疗方法,如电刺激和p物质。伤口治疗研究的一个有前途的领域是使用骨髓来源的干细胞治疗,在动物模型中研究表明,这些干细胞能够分化成角质……
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The principles of wound healing
Wound healing is an ever-changing field, as new insights are made into its mechanisms through basic science research, thus driving development of new therapies. In this paper, we present the current molecular models of wound healing and scar formation in the three phases: inflammation, proliferation and remodeling. New cellular signaling pathways such as mechanotransduction through the transforming growth factor-beta and integrin pathways have opened up various targets for wound therapy. Other therapies such as negative pressure devices and anti-microbial peptides are being improved as more data becomes available. Cutting edge treatments in gene therapy like Regranex are under heavy investigation, as are various treatments whose molecular mechanisms remain to be elucidated such as electrostimulation and Substance P. A promising area in wound treatment research is the use of bone marrow derived stem cell therapy, where research in animal models has shown these stem cells are able to differentiate into kera...
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