Pharmaco–cold cardioplegia during isolated prosthesis of the aortal valve

Objective. To study the possibilities of pharmaco–cold cardioplegia, while doing isolated prosthesis of the aortal valve. Materials and methods. Into the investigation were included 279 patients with aortal failures, operated in Department of Surgical Treatment of the Acquired Failures of the Heart of National Institute of Cardio–Vascular Surgery named after М. М. Аmosov in 2015–2021 yrs. The average age of the patients have constituted (62,5 ± 6,4) yrs old. In all the patients the isolated аоrtal valve correction for aortal failures was performed, using mechanical and biological prostheses. Infusion of “Kustodiol” solution for defense of the myocardium was applied. Results. On the hospital stage 9 patients died (hospital lethality have constituted 3,2%). Іnotropic support (dobutamin) in early postoperative period was applied in  dosage of 3 – 4 mcg/kg/min during first 48 h. The levels of cardiac creatine phosphokinase enzyme on the second postoperative day, while exploiting antegrade, аnteretrograde, retroantegrade and retrograde methods of the cardioplegic solution delivery, have hade differences. Conclusion. Retrograde pathway of injection of cardioplegic solution permits to defense the myocardium effectively while correcting of aortal failure.