PON1 和 APOE 多态性与 2 型糖尿病患者血浆脂质水平和晚期并发症风险的关系。

IF 2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Medical Biochemistry Pub Date : 2023-10-27 DOI:10.5937/jomb0-43154

Jasna Klen, Katja Goričar, Vita Dolžan

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引用次数: 0

摘要

背景：除了良好的血糖控制，控制血脂水平也能有效预防或延缓 2 型糖尿病（T2D）后期并发症。由于载脂蛋白 E（APOE）和副氧自由基酶 1（PON1）具有抑制动脉粥样硬化的作用，我们研究了常见功能性 PON1 和 APOE 多态性与 T2D 患者血浆脂质水平和晚期并发症风险的关系：我们的回顾性遗传关联研究纳入了 181 名 T2D 患者，对 PON1 rs622、PON1 rs854560、APOE rs429358 和 APOE rs7412 进行了基因分型。

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The associations of PON1 and APOE polymorphisms with plasma lipid levels and the risk for late complications in type 2 diabetes patients.

Background: Besides good glycemic control, also control of lipid levels can effectively prevent or delay late type 2 diabetes (T2D) complications. As apolipoprotein E (APOE) and paraoxonase 1 (PON1) were shown to suppress atherosclerosis, we investigated the associations of common functional PON1 and APOE polymorphisms with plasma lipid levels and the risk for late complications in T2D patients.

Methods: Our retrospective genetic association study included 181 T2D patients genotyped for PON1 rs622, PON1 rs854560, APOE rs429358 and APOE rs7412.

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.