M. Sidorova, E. Rybnikova, A. Churilova, V. Portnichenko, M. O. Sanoĭlov
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[The effect of mild hypobaric hypoxia regime on expression of factor induced by hypoxia in the rat neocortex].
Using quantitative immunohistochemistry, modifications of HIF-1alpha expression in neocortex of rats exposed to various modes of mild hypobaric hypoxia (MHH) (1,3 and 6 episodes) differed in their neuroprotective efficacy have been studied. It has been shown that three-trial MHH being the most effective neuroprotective mode when used as a preconditioning produces most considerable changes in HIF-1 by substantial up-regulation of its regulatory alpha-subunit expression in the rat neocortex. Present findings support the hypothesis on important roles of HIF-1 in the mechanisms of brain hypoxic tolerance induced by the hypoxic preconditioning with three-trial MHH.
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