复合维生素b的回顾、展望与展望:维生素的包封与从含维生素聚合物中释放

F. Parın
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引用次数: 1

摘要

维生素被认为是至关重要的营养素,因为当它们结合在一起时,它们在体内发挥着数百种功能。它们能强健骨骼,治愈伤口,增强免疫系统。此外,它们还能将食物转化为能量,治愈细胞损伤。在这方面,b族复合维生素,如硫胺素、核黄素和烟酸是可溶性维生素,在能量代谢酶活动中起辅酶作用,是健康身体的组成部分。然而,复合维生素b对光线、pH值和温度都很敏感。因此,它们在用于药品之前必须被封装。近年来,主要集中在减少药物的降解或损失,提高药物的生物利用度,限制不良反应,改善药物在靶向部位的蓄积。为了在规定的治疗期间保持最佳的生物利用度,从控释产物中释放的药物剂量的比例必须足够大,以适应同一时期体内代谢和/或消除的活性药物的数量。药物释放系统还旨在提高药物的有效性并治疗受损区域。在本章中,旨在研究各种形式的维生素负载聚合物体系的生产,如微/纳米颗粒、胶束、水凝胶、脂质体和纳米纤维,以及在制药和生物医学应用中的释放研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Retrospective, Perspective and Prospective of B-Complex Vitamins: Encapsulation of Vitamins and Release from Vitamin-Loaded Polymers
Vitamins are regarded as vital nutrients because, when combined, they performed hundreds of functions in the body. They strengthen bones, heal wounds, and boost your immune system. In addition, they transform food into energy and heal cellular damage. In this regard, B-complex vitamins, such as thiamine, riboflavin, and niacin are soluble vitamins that serve as coenzymes in energy metabolism enzymatic activities which building blocks of a healthy body. However, B-complex vitamins are sensitive to light, pH conditions, and temperature. Consequently, they must be encapsulated before they may be used in pharmaceuticals. Recently, it is mainly focused on reducing drug degradation or loss, increase drug bioavailability, limit adverse effects, and improve drug accumulation in the targeted location. To maintain optimum bioavailability during a defined term of therapy, the fraction of drug dosage released from a controlled release product must be significant enough to adjust for the quantity of active drug metabolized and/or eliminated from the body over the same period. Drug release systems also aim to increase the effectiveness of the drug and treat the damaged area. In this chapter, it is aimed to study the production of the vitamin-loaded polymer systems in various forms, such as micro/nanoparticles, micelle, hydrogel, liposome, and nanofiber, as well as release studies in pharmaceutical and biomedical applications.
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