“绿色”激光应用于皮肤毛细血管发育不良选择性光破坏的实验证实

N. Gorbatova, D. Safin, E. Gasanova, A. Sirotkin, G. Kuzmin, A. Tertychny, O. Tikhonevich, M. Remennicova, S. Zolotov
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引用次数: 1

摘要

基本原理。现有的治疗皮肤毛细血管发育不良的技术,包括“激光”光破坏,是不够有效的,经常导致不希望的热损伤和皮肤瘢痕畸形。因此,有效去除这种血管病变仍然是相关的,需要进一步的解决方案。研究波长525 nm的“绿”激光照射后的热损伤性质和创面再生过程,探讨其是否可用于选择性光破坏包括皮肤毛细血管发育不良在内的上皮下病理性血管结构。材料和方法。以活白鸡扇贝为血管结构的生物模型进行体内研究。实验采用波长为525 nm的固体激光器产生“绿色”光。这种激光在皮肤毛细血管中发现的血红蛋白和氧合血红蛋白的吸收系数有相似的峰值。利用形态学、宏观和组织学检查的结果,研究了辐照区血管结构模型的损伤特征和再生过程的动力学。本实验结果表明,选择性光破坏扇贝上皮下血管结构是可能的,对包括生长带在内的上皮损伤最小。在辐照区,由于上皮下区血管腔的闭合和胶原层的形成,可以看到表面的美白和光滑,以及伤口表面在生理上的上皮化,而没有形成皮肤的瘢痕变形。525 nm“绿色”激光对上皮下血管结构的选择性作用已被证实,皮肤损伤最小。它开辟了一条途径,应用这种光选择性光破坏毛细血管发育不良的皮肤,具有良好的临床和美学效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Experimental substantiation of «green» laser light application for selective photodestruction of capillary angiodysplasia of the skin
Rationale. The existing techniques for treating skin capillary angiodysplasias, including «laser» photodestruction, are not effective enough and often cause undesirable thermal damage and cicatricial deformities of the skin. Thus, the effective removal of this vascular pathology is still relevant and requires further solution.Purpose. To study the nature of thermal injuries and wound regenerative processes after «green» laser irradiation with wavelength 525 nm so as to find out if it may be used for selective photodestruction of subepithelial pathological vascular structures, including angiodysplasias of skin capillaries.Material and Methods. Scallops of alive white chickens were taken as a biological model of vascular structures for in vivo studies. An experimental solid-state laser generating «green» light with wavelength 525 nm was used. This laser light has similar peaks of the absorption coefficient of hemoglobin and oxyhemoglobin which are found in skin capillaries. Features of damage and dynamics of regenerative process in the irradiated area were studied at the model of vascular structures using findings of morphological macroscopic and histological examinations.Results. Findings of the present experimental trial have inspired that selective photodestruction of subepithelial vascular structures of scallops is possible with minimal damage to the epithelium, including growth zones. In irradiated areas, one could see whitening and smoothing of the surface due to closure of vessel lumens in the subepithelial zone and formation of collagenosis layer there, as well as epithelialization of wound surface in physiological terms without any formation of cicatricial deformation of the skin.Conclusion. The selective effect of 525 nm «green» laser light at subepithelial vascular structures with minimal skin damage has been confirmed. It opens a way to apply this light for selective photodestruction of capillary angiodysplasias of the skin with good clinical and esthetic outcomes.
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期刊介绍: The main columns of "Chinese Journal of Laser Medicine & Surgery" include treatises, which report the latest research results in basic research and clinical trials in the field of laser medicine; comprehensive reviews of the latest research progress in laser medicine at home and abroad. In addition, there are short reports and excerpts from foreign journals, conference news and other columns. The journal has published a large number of papers on basic research on laser medicine and applied research in various clinical subjects, aiming to play a positive role in promoting the application of laser in medicine and improving the level of laser medicine research.
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