Antitoxic Effects of Solanum betaceum cav. Peel Skin Extract

Background: In Indonesia, Solanum betaceum cav is a traditional herbal medicine which their skin is often wasted because not many people known its content. Aims: To find out the anti-toxic effect of Solanum betaceum cav peel skin ethanol extract on rat’s renal post-carrageenan induction. Study Design: Laboratory experimental in vivo study. Place and Duration of Study: This research was done at Animal Research Facilities (ARF) Medical Faculty University of Indonesia, at September to December 2021. Methodology: The samples used in this research are male white mice, Wistar strain (Rattus norvegicus) with the body weight 180–220 gram which divided into 5 groups, negative control (saline), positive control (sodium dilcofenac 7mg/kgBW), and Solanum betaceum Cav. peel skin ethanol extract groups (70mg/kgBW, 140mg/kgBW, and 280mg/kgBW).  Mice’s buccal mucosa was injected with Caraagenan 1%. Macroscopic and microscopic observation was done before, 24 hours, 48 hours and 72 hours post caraagenan injection. Results: Phytochemical test showed that Solanum betaceum Cav. peel skin ethanol extract contains phenolic, flavonoid, tannin, and alkaloid. At all doses, anti-toxic effect of Solanum betaceum Cav. peel skin ethanol extract have same healing effectiveness within 48 hours. In positive control, the renal were normal at 48 hours. Meanwhile, the negative control’s healing effectiveness was seen at 72 hours. Conclusion: The anti-toxic effect of Solanum betaceum Cav. peel skin ethanol extract has effective healing process at all doses in 48 hours post-carrageenan induction without affect rats’ body weight, however with lower intensity than positive control which using dilcofenac as anti-inflammatory drug.