维拉帕米及其在糖尿病中的作用

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM
Paul Zimmermann, F. Aberer, M. Eckstein, Sandra Haupt, Maximilian P. Erlmann, O. Moser
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引用次数: 2

摘要

自身免疫性胰腺β细胞的损失和破坏在1型糖尿病的发病和发展中起着关键作用,并有可能增加发生微血管和大血管并发症的风险。在这方面,口服维拉帕米是一种钙通道拮抗剂,通常用作抗心律失常药物,先前已显示出对新发1型糖尿病患者β细胞保存的潜在有益作用。此外,观察数据表明,2型糖尿病的发病风险降低。其潜在的病理生理机制尚未得到很好的研究,并且仍然没有定论。这篇叙述性综述的目的是详细介绍维拉帕米在促进内源性β细胞功能方面的作用,它可能有资格用于1型糖尿病的早期治疗,并总结有关其对2型糖尿病患者血糖影响的现有证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Verapamil and Its Role in Diabetes
Autoimmune pancreatic β-cell loss and destruction play a key role in the pathogenesis and development of type 1 diabetes, with a prospective increased risk for developing micro- and macrovascular complications. In this regard, orally administrated verapamil, a calcium channel antagonist, usually intended for use as an anti-arrhythmic drug, has previously shown potential beneficial effects on β-cell preservation in new-onset type 1 diabetes. Furthermore, observational data suggest a reduced risk of type 2 diabetes development. The underlying pathophysiological mechanisms are not well investigated and remain widely inconclusive. The aim of this narrative review was to detail the role of verapamil in promoting endogenous β-cell function, potentially eligible for early treatment in type 1 diabetes, and to summarize existing evidence on its effect on glycemia in individuals with type 2 diabetes.
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CiteScore
2.50
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