暴露于n-亚硝胺的受试者的胃幽门螺杆菌粘膜活检中p62~(泛myc)的表达增加

The Journal of Beijing Medical University Pub Date : 1900-01-01 DOI:10.1097/00008469-199609001-00042

D. Daju

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引用次数: 0

摘要

方法:采用免疫化学组织学方法和液体移动光解-热解能量分析仪，同时研究了胃组织中pan-myc的表达和空腹胃液中总n-亚硝胺的浓度。结果:胃液样品，57。1%检测到n -亚硝胺。在6例胃活检中发现p62pan-myc在粘膜上皮细胞中的表达。所有6例p62pan-myc阳性活检均来自胃液n-亚硝胺可检出的患者，而在胃液n-亚硝胺不可检出的15例患者中未发现p62pan-myc阳性活检(P= 0.05)。0239)。在p21pan-ras、p185c-erbB-2和p53突变体p53中没有观察到这种关系。结论:这些结果首次表明myc癌基因的表达与n -亚硝胺暴露在人胃中呈正相关，myc癌基因可能在n -亚硝胺致人胃癌的早期阶段发挥作用。

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INCREASED EXPRESSION OF p62~(pan-myc) IN GASTRIC PYLORI MUCOSA BIOPSIES FROM SUBJECTS EXPOSED TO N-NITROSAMIDES

To elucidate the possible role of myc oncogene in human gastric carcinogenesis byN-nitrosamides Methods: Expression of pan-myc in gastric biopsies of pylori and concentration of totalN-nitrosamides in fasting gastric juice samples were studied simultaneously with immunochemohistological method and liquid mobile-photohydrolysis-pyrolysis energy analyzer. Results: Ofgastric juice samples, 57. 1 % were N-nitrosamide-detectable. Evaluation of p62pan-myc in mucosal epithelial cells Was found in 6 gastric biopsies. All the 6 p62pan-myc-positive biopsies were from patients whosegastric juices were N-nitrosamide-detectable, whereas no p62 pan-myc-positive biopsy was found inthose from 15 cases whose gastric juices were N-nitrosamide-undetectab1e (P= 0. 0239). Such relationwas not observed for p21pan-ras, p185c-erbB-2, and p53mutant p53. Conclusion: These results indicate firstlythat expression of myc oncogene correlated with the exposure to N-nitrosamides in human stomach positively and myc oncogene may play a role in the early stage of human gastric carcinogenesis by N-nitrosamides.

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The Journal of Beijing Medical University

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