PREPARATION OF Sr-CONTAINING BONE LIKE APATITE CEMENT

Amorphous calcium phosphate (ACP) is a known precursor of apatite, which is one of the main components of human bone. Synthesized ACP transforms into low-crystallinity hydroxyapatite (HAp) around body temperature. Thus, if low-crystallinity calcium phosphate cement, containing active ingredients for bone repair, can be prepared at around 0oC, it is expected to be a suitable material for the controlled-release of active ingredients. Sr was reported to promote a cytokine, which inhibited the formation of osteoclasts. Thus, Sr-doped ACP is expected to be a controlled-release material and can promote bone formation. In this study, we synthesized Sr-doped ACP powder by wet synthesis, and prepared Sr-doped calcium phosphate cement. The cement has potential for use as a new type of bone substitute. (Received January 1, 2016; Accepted April 4, 2016)