荆芥提取物对d -半乳糖致大鼠皮肤衰老模型的抗衰老作用

Pharmacology & Pharmacy Pub Date : 2018-10-23 DOI:10.4236/PP.2018.910032

G. Sukoyan, Edisher E. Tsivtsivadze, V. V. Golovach, T. Kezeli, N. Demina

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引用次数: 5

摘要

本研究旨在评价2%棘草提取物对d -半乳糖诱导的皮肤衰老模型大鼠胶原代谢紊乱和炎症的逆转作用。d -半乳糖致衰老主要实验组48只，对照组12只。主组随机分为4组:1 .老化+生理盐水，2 - 4 .不同厂家2%洋蓟提取物(绿原酸含量2.5%)，皮内注射0.13 mg，每周2次，共4周。洋蓟提取物恢复皮肤相对重量，提高皮肤在中性盐和酸中的溶解度，降低胃蛋白酶溶解度，恢复己糖胺/胶原(羟脯氨酸)比，降低核转录因子(NF-kB)活性。在d -半乳糖诱导的皮肤衰老模型中，洋蓟提取物局部延长治疗可改善胶原代谢，减轻炎症进展。

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Anti-Aging Effect of Cynara cardunculus L. var. Cynara scolymus L. Extract in D-Galactose-Induced Skin Aging Model in Rats

The aim of the study was to evaluate the efficacy of 2% Cynara scolymus L. extracts in reverse disturbances of collagen metabolism and inflammation in D-galactose induced skin aging model in rats. D-galactose induced aging reproduced in 48 animals of main group, and 12 rats in control group. All animals in main group were randomized for 4 groups: I. aging + saline, II - IV. different manufacturers 2% artichoke extracts (with content of chlorogenic acid 2.5%) in a dose of intradermal injection 0.13 mg twice at weeks during 4 weeks. Influence of artichoke extracts restored skin relative weight and led to an increase of solubility in neutral salt and acid, and decreased pepsin solubility collagen fraction, restored the hexosamine/collagen (hydroxyproline) ratio and decreased the activity of nuclear transcription factor (NF-kB). Local prolonged treatment with artichoke extracts improved collagen metabolism and attenuated the progression of inflammation in D-galactose induced skin aging model.

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Pharmacology & Pharmacy

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