Sahinturk Kadriye, Abakay Candan Demiroz, Sahinturk Serdar, Sag Sebnem Ozemri, Atalay Fatma, Can Fatma E, Kurt Meral, Cetintas Sibel Kahraman
{"title":"MSI对子宫内膜样腺癌术后放疗预后影响的研究","authors":"Sahinturk Kadriye, Abakay Candan Demiroz, Sahinturk Serdar, Sag Sebnem Ozemri, Atalay Fatma, Can Fatma E, Kurt Meral, Cetintas Sibel Kahraman","doi":"10.23937/2378-3419/1410128","DOIUrl":null,"url":null,"abstract":"In this study, the relationship between MSI (microsatellite instability) and the parameters such as age, stage, histologic grade, recurrence, overall survival (OS), disease free survival (DFS) were investigated in 99 endometrioid adenocancer patients. Our aim is to find out the whether there is a prognostic value of MSI in endometrium adenocarcinoma. In MSI analysis, by employing the Promega MSI Analysis System. ‘IBM SPSS v.20’ was used for statistical analysis. MSI was identified in 19.1% of patients. There was no statistically significant effect of MSI on OS (p = 0.404) or on DFS (p = 0.407). MSI was found associated with younger age (p = 0.032), lymph node involvement (p = 0.012) and advanced stage (p = 0.014).","PeriodicalId":13873,"journal":{"name":"International journal of cancer and clinical research","volume":"8 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Research of Prognostic Role of MSI in Endometrioid Adenocarcinoma Cases That Received Postoperative Radiotherapy\",\"authors\":\"Sahinturk Kadriye, Abakay Candan Demiroz, Sahinturk Serdar, Sag Sebnem Ozemri, Atalay Fatma, Can Fatma E, Kurt Meral, Cetintas Sibel Kahraman\",\"doi\":\"10.23937/2378-3419/1410128\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this study, the relationship between MSI (microsatellite instability) and the parameters such as age, stage, histologic grade, recurrence, overall survival (OS), disease free survival (DFS) were investigated in 99 endometrioid adenocancer patients. Our aim is to find out the whether there is a prognostic value of MSI in endometrium adenocarcinoma. In MSI analysis, by employing the Promega MSI Analysis System. ‘IBM SPSS v.20’ was used for statistical analysis. MSI was identified in 19.1% of patients. There was no statistically significant effect of MSI on OS (p = 0.404) or on DFS (p = 0.407). MSI was found associated with younger age (p = 0.032), lymph node involvement (p = 0.012) and advanced stage (p = 0.014).\",\"PeriodicalId\":13873,\"journal\":{\"name\":\"International journal of cancer and clinical research\",\"volume\":\"8 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of cancer and clinical research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.23937/2378-3419/1410128\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of cancer and clinical research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.23937/2378-3419/1410128","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Research of Prognostic Role of MSI in Endometrioid Adenocarcinoma Cases That Received Postoperative Radiotherapy
In this study, the relationship between MSI (microsatellite instability) and the parameters such as age, stage, histologic grade, recurrence, overall survival (OS), disease free survival (DFS) were investigated in 99 endometrioid adenocancer patients. Our aim is to find out the whether there is a prognostic value of MSI in endometrium adenocarcinoma. In MSI analysis, by employing the Promega MSI Analysis System. ‘IBM SPSS v.20’ was used for statistical analysis. MSI was identified in 19.1% of patients. There was no statistically significant effect of MSI on OS (p = 0.404) or on DFS (p = 0.407). MSI was found associated with younger age (p = 0.032), lymph node involvement (p = 0.012) and advanced stage (p = 0.014).
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