- Book学术

发布求助

文献互助智能选刊最新文献

JURNAL ILMIAH SAINS Pub Date : 2020-09-13 DOI:10.35799/jis.20.2.2020.28857

Nur Alam, I. Budiarsa, Dewi Tureni

{"title":"Prediksi Struktur Tiga Dimensi Protein β-NGF (Nerve Growth Factor) Burung Merpati (Columba livia)","authors":"Nur Alam, I. Budiarsa, Dewi Tureni","doi":"10.35799/jis.20.2.2020.28857","DOIUrl":null,"url":null,"abstract":"Protein β-NGF berperan dalam kelangsungan hidup sel neuron dan diferensiasi embrio aves yang diekspresikan oleh gen NGF. Informasi protein β-NGF telah diidentifikasi pada ayam dan masih terbatas dilaporkan pada merpati. Tujuan penelitian adalah memprediksi struktur tiga dimensi protein β-NGF merpati untuk menambah informasi karakter proteinnya. Protein target diperoleh dari server UniProt dengan kode akses B4ZE95. Prediksi struktur tiga dimensi dan karakterisasi protein β-NGF menggunakan server SWISS-MODEL dan program Chimera. Hasil analisis menunjukkan bahwa protein β-NGF merpati dan template memiliki nilai identity sebesar 89,91%, QMEAN 0,51 serta GMQE sebesar 0,44. Struktur tiga dimensi protein B4ZE95 memiliki asam amino hidrofobik (Ile, Leu, Trp, Phe, Val, Ala, Gly, Met, Cys); karboksil (Glu, Ser, Asp); amina (Lys, Thr) dengan 83 ikatan hidrogen.Kata kunci: columba livia, chimera, protein β-NGF, swiss-model Three Dimensional Protein Structure Prediction of β-NGF(Nerve Growth Factor) on Pigeon (Columba livia)ABSTRACTThe β-NGF protein plays a role in the survival of neuron cells and differentiation of avian embryo which is expressed by NGF gene. Information of β -NGF protein was identified in chicken and it is still limited reported in pigeon. The purpose of this study is to predict the three-dimensional structure of pigeon β-NGF protein to add information about its protein character. The target protein is obtained from UniProt server with access code B4ZE95. The prediction of three-dimensional structure and characterization of β-NGF protein were carried out using SWISS-MODEL server and Chimera program. The analysis showed that pigeon β-NGF protein and template had identity of 89,91%, QMEAN 0,51 and GMQE of 0,44. The three-dimensional structure of the B4ZE95 protein has hydrophobic amino acids namely (Ile, Leu, Trp, Phe, Val, Ala, Gly, Met, Cys); carboxyl namely (Glu, Ser, Asp); amine namely (Lys, Thr) with 83 hydrogen bonds.Keywords: columba livia, chimera, protein β-NGF, swiss model","PeriodicalId":17715,"journal":{"name":"JURNAL ILMIAH SAINS","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"JURNAL ILMIAH SAINS","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.35799/jis.20.2.2020.28857","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 1

摘要

β蛋白-NGF神经元细胞和胚胎分化的生存中扮演了重要角色aves NGF表达的基因。β蛋白信息-NGF已被确认在鸡和鸽子还在有限的报道。研究的目的是预测蛋白质的三维结构β-NGF鸽子来补充蛋白质的角色信息。目标蛋白质是从带有B4ZE95访问码的UniProt服务器上获取的。预测和描述蛋白质三维结构β-NGF使用SWISS-MODEL服务器和嵌合体项目。分析结果表明,β蛋白-NGF鸽子有身份价值高达89,91%模板,QMEAN 0,51以及GMQE 44万。蛋白质的三维结构B4ZE95含有水溶液氨基酸(Ile, Leu, Trp, Phe, Val, Ala, Gly, Met, Cys);熔融剂(Glu，爵士，Asp);有83个氢键。关键词:columba livia嵌合体,β蛋白蛋白质-NGF, swiss-model三易位vesalius Prediction ofβ-NGF神经增长因子)在鸽子(columba livia) ABSTRACTTheβ-NGF蛋白质剧作a角色在《鸟类生存的神经元细胞和differentiation音频,这是expressed由NGF吉恩。资讯网的β-NGF蛋白质是在鸡和identified还是限量reported in鸽子。《three-dimensional这个研究的目的是为了预测vesalius鸽子的β-NGF to add资讯网关于它的蛋白质蛋白质character。目标蛋白质来自UniProt服务器，带有access code B4ZE95。《three-dimensional prediction vesalius》和βcharacterization -NGF蛋白质是用SWISS-MODEL carried out和嵌合体服务器程序。《分析》那里那鸽子β-NGF蛋白质》和89,91%模板有身份,QMEAN 0,51》和44 GMQE。B4ZE95蛋白质的三维结构有氨基酸acique namely水样(Ile, Leu, Trp, Phe, Val, Ala, Gly, Cys);carboxyl namely (Glu, Ser, Asp);含83枚氢弹的安装:columba livia嵌合体,β蛋白-NGF,瑞士模型

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Prediksi Struktur Tiga Dimensi Protein β-NGF (Nerve Growth Factor) Burung Merpati (Columba livia)

Protein β-NGF berperan dalam kelangsungan hidup sel neuron dan diferensiasi embrio aves yang diekspresikan oleh gen NGF. Informasi protein β-NGF telah diidentifikasi pada ayam dan masih terbatas dilaporkan pada merpati. Tujuan penelitian adalah memprediksi struktur tiga dimensi protein β-NGF merpati untuk menambah informasi karakter proteinnya. Protein target diperoleh dari server UniProt dengan kode akses B4ZE95. Prediksi struktur tiga dimensi dan karakterisasi protein β-NGF menggunakan server SWISS-MODEL dan program Chimera. Hasil analisis menunjukkan bahwa protein β-NGF merpati dan template memiliki nilai identity sebesar 89,91%, QMEAN 0,51 serta GMQE sebesar 0,44. Struktur tiga dimensi protein B4ZE95 memiliki asam amino hidrofobik (Ile, Leu, Trp, Phe, Val, Ala, Gly, Met, Cys); karboksil (Glu, Ser, Asp); amina (Lys, Thr) dengan 83 ikatan hidrogen.Kata kunci: columba livia, chimera, protein β-NGF, swiss-model Three Dimensional Protein Structure Prediction of β-NGF(Nerve Growth Factor) on Pigeon (Columba livia)ABSTRACTThe β-NGF protein plays a role in the survival of neuron cells and differentiation of avian embryo which is expressed by NGF gene. Information of β -NGF protein was identified in chicken and it is still limited reported in pigeon. The purpose of this study is to predict the three-dimensional structure of pigeon β-NGF protein to add information about its protein character. The target protein is obtained from UniProt server with access code B4ZE95. The prediction of three-dimensional structure and characterization of β-NGF protein were carried out using SWISS-MODEL server and Chimera program. The analysis showed that pigeon β-NGF protein and template had identity of 89,91%, QMEAN 0,51 and GMQE of 0,44. The three-dimensional structure of the B4ZE95 protein has hydrophobic amino acids namely (Ile, Leu, Trp, Phe, Val, Ala, Gly, Met, Cys); carboxyl namely (Glu, Ser, Asp); amine namely (Lys, Thr) with 83 hydrogen bonds.Keywords: columba livia, chimera, protein β-NGF, swiss model

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

JURNAL ILMIAH SAINS

自引率

0.00%

发文量