Kisspeptin调节反刍动物的繁殖

Q4 Veterinary

Iranian Journal of Veterinary Science and Technology Pub Date : 2018-04-21 DOI:10.37591/RRJOVST.V5I1.515

M. Mondal, K. K. Baruah, M. Ghosh, M. Karunakaran, T. K. Dutta

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引用次数: 1

摘要

Kisspeptin是由KiSS1基因及其同源基因KiSS1R编码的神经肽，是动物生殖的关键调控因子。Kisspeptin，也被称为metastin，是一种有效的促性腺激素释放激素(GnRH)的分泌剂。它刺激大脑中的GnRH神经元，产生GnRH的脉冲，从而使其分泌和释放，这反过来又刺激了LH和FSH的释放。由于其在生殖生物学中的重要性，kisspeptin-KiSS1R系统目前被认为是动物繁殖的重要看门人。除中枢神经系统外，Kisspeptin在胎盘和妊娠过程中的作用已被证实。因此，kisspeptin-KiSS1R系统可能在动物生殖中发挥多种作用。本文就kisspeptin在反刍动物繁殖中的作用及生理意义进行综述。关键词:Kisspeptin, KiSS1，转移蛋白，KiSS1R，繁殖，反刍动物，GnRH, LHKisspeptin调节反刍动物的繁殖。研究综述:Journal of Veterinary Science and Technology. 2016;5 (1): 7-12p

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Kisspeptin Modulates Reproduction in Ruminants

Abstract Kisspeptin, a neuropeptide encoded by the KiSS1 gene and its cognate, KiSS1R are the key regulators of reproduction in animals. Kisspeptin, also known as metastin, is a potent secretagogue of gonadotropin-releasing hormone (GnRH). It stimulates the GnRH neurons in the brain and generates pulses for GnRH thereby its secretion and release, and this in turn stimulates the release of LH and FSH. Owing to its importance in reproductive biology, the kisspeptin-KiSS1R system is presently regarded as an essential gatekeeper of reproduction in animals. Besides central nervous system, role of Kisspeptin during the process of placentation and pregnancy has been established recently. Therefore, kisspeptin-KiSS1R system potentially plays diverse roles in animal reproduction. Here, we review the role and physiological significance of kisspeptin in the reproduction of ruminants. Keywords: Kisspeptin, KiSS1, metastin, KiSS1R, reproduction, ruminant, GnRH, LH Cite this Article M. Mondal, K.K. Baruah, M.K. Ghosh, M. Karunakaran, T.K. Dutta. Kisspeptin modulates reproduction in ruminants. Research & Reviews: Journal of Veterinary Science and Technology. 2016; 5(1): 7–12p

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来源期刊

Iranian Journal of Veterinary Science and Technology Veterinary-Veterinary (all)

CiteScore

0.40

自引率

0.00%

发文量

审稿时长

30 weeks