莪术精油对银屑病皮损中耐甲氧西林金黄色葡萄球菌的抑菌活性研究

Maryam Nilghaz, Masoumeh Mahdavi-Ourtakand, F. Noorbakhsh
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引用次数: 0

摘要

背景和目的:银屑病是一种慢性炎症性皮肤病,目前尚无明确的治疗方法。已经确定了几种微生物制剂在银屑病的恶化中起作用,其中之一是金黄色葡萄球菌。耐甲氧西林金黄色葡萄球菌(MRSA)菌株的增加是世界范围内的主要问题。本研究旨在评价莪术精油对牛皮癣患者皮损处分离的MRSA菌株的抑菌作用。方法:在这项研究中,参与者是伊朗德黑兰sharati医院皮肤科和风湿病诊所的140例牛皮癣患者。诊断试验包括革兰氏染色、过氧化氢酶试验、试管凝固酶试验、甘露醇发酵试验和脱氧核糖核酸酶试验。为鉴定MRSA菌株的表型,采用头孢西丁纸片扩散法进行甲氧西林药敏试验。采用肉汤微量稀释法研究肉桂精油的抑菌活性,并计算其对MRSA菌株的最低抑菌浓度。结果:140例患者中,金黄色葡萄球菌感染43.57%,MRSA感染14.28%。MRSA感染患者的性别、年龄和采样区域无显著相关性。结果表明,莪术精油对MRSA菌株有一定的抑菌作用。结论:莪术精油可作为抗生素的替代品,用于控制和治疗金黄色葡萄球菌引起的皮肤感染。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antibacterial Activity of Cinnamomum Zeylanicum Essential Oil Against Methicillin-resistant Staphylococcus Aureus Strains Isolated From Skin Lesions In Patients With Psoriasis
Background and Objectives: Psoriasis is a chronic and inflammatory skin disease, which is has no definitive cure. Several microbial agents have been identified that have a role in the exacerbation of psoriasis, one of which is Staphylococcus aureus. Increased Methicillin-resistance Staphylococcus aureus (MRSA) strains is a major problem worldwide. This study aims to evaluate the antibacterial effect of Cinnamomum zeylanicum essential oil on MRSA strains isolated from skin lesions in patients with psoriasis. Methods: In this study, participants were 140 patients with psoriasis referred to the dermatology and rheumatology clinic of Shariati Hospital in Tehran, Iran. Diagnostic tests including gram staining, catalase test, tube coagulase test, mannitol fermentation test, and deoxyribonuclease test were performed. To identify the phenotype of MRSA strains, methicillin susceptibility testing was performed using cefoxitin by disk diffusion method. The antimicrobial activity of Cinnamomum zeylanicum essential oil was investigated by broth microdilution method and its minimum inhibitory concentration against MRSA strains was calculated. Results: Of 140 patients, 43.57% had infection with Staphylococcus aureus and 14.28% had MRSA infection. There was no significant relationship between gender, age and sampling area in patients with MRSA infection. The results showed that Cinnamomum zeylanicum essential oil had antimicrobial effects on MRSA strains. Conclusion: The Cinnamomum zeylanicum essential oil can be a suitable alternative to antibiotics for the control and treatment of skin infections caused by Staphylococcus aureus.
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