MMP-9和TGF-1β在评估慢性丙型肝炎GT -1感染患者肝纤维化严重程度及其进展率中的诊断价值

IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL
CD O. V H. V. Venytska B, Riabokon, DE R. O Yu. Yu. Riabokon C, Shcherbyna
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引用次数: 0

摘要

的目标。我们的工作目的是发现血清MMP-9和TGF-1β测定在慢性丙型肝炎基因1型(CHC GT1)感染患者肝纤维化严重程度及其进展率的诊断价值。材料和方法。对92例CHC GT1患者进行了检查。采用弹性测量法评估肝纤维化的严重程度。采用T. Poynard公式计算肝纤维化进展率。ELISA法检测血清TGF-1β、MMP-9水平。在CHC GT1患者中,f3 - 4存在时,纤维发生/纤溶的血清参数变化最为明显。血清TGF-1β >12.03 pg/ml (p < 0.001)、MMP-9≤987.20 pg/ml (p = 0.016)、TGF-1β/MMP-9比值>0.011 (p < 0.001)时,F- 4 ~ 4期肝纤维化发生的概率较高。f3 - 4比f0 - 2更常出现快速肝纤维化进展(62.9%比16.7%,p < 0.0001)。与肝纤维化进展缓慢的患者相比,这些患者的TGF-1β/MMP-9比值较高,证实了肝纤维化进展速度加快(p < 0.05)。血清TGF-1β >8.69 pg/ml (p < 0.001)、MMP-9≤920.65 (p = 0.005)、TGF-1β/MMP-9比值> 0.011 (p < 0.001)时,肝纤维化快速进展的概率较高。MMP-9和TGF-1β在评估CHC GT1患者肝纤维化严重程度及其进展率方面的诊断价值已经确定。已经提出了MMP-9、TGF-1β和TGF-1β/MMP-9比值的临界值用于重度肝纤维化患者的分层及其快速进展率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diagnostic values of MMP-9 and TGF-1β in assessing the severity of liver fibrosis and the rate of its progression in patients with chronic hepatitis C GT 1 infection
Aim. The purpose of our work is to find out diagnostic values of serum MMP-9 and TGF-1β determination for assessing the severity of liver fibrosis and the rate of its progression in patients with chronic hepatitis C genotype 1 (CHC GT1) infection. Materials and methods. 92 patients with CHC GT1 were examined. The severity of liver fibrosis was assessed by elastometry. The rate of liver fibrosis progression was calculated using the T. Poynard formula. Serum levels of TGF-1β and MMP-9 were measured by ELISA method. Results. In patients with CHC GT1, the most noticeable changes in the serum parameters of fibrogenesis / fibrinolysis were observed in the presence of F 3–4. The probability of liver fibrosis stages F 3–4 was high at the serum levels of TGF-1β >12.03 pg/ml (p < 0.001), MMP-9 ≤987.20 pg/ml (p = 0.016), TGF-1β/MMP-9 ratio >0.011 (p < 0.001). Fast liver fibrosis progression was more often registered in F 3–4 than in F 0–2 (62.9 % vs. 16.7 %, p < 0.0001). Increasing rate of liver fibrosis progression in these patients was confirmed by a higher ratio of TGF-1β/MMP-9 compared to that in patients with a slow rate of liver fibrosis progression (p < 0.05). The probability of fast liver fibrosis progression was high at the serum levels of TGF-1β >8.69 pg/ml (p < 0.001), MMP-9 ≤920.65 (p = 0.005), TGF-1β/MMP-9 ratio > 0.011 (p < 0.001). Conclusions. The diagnostic value of MMP-9 and TGF-1β in assessing the liver fibrosis severity and the rate of its progression in patients with CHC GT1 has been defined. Cut-off levels of MMP-9, TGF-1β and the TGF-1β/MMP-9 ratio for stratification of patients with severe liver fibrosis and the fast rate of its progression have been proposed.
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来源期刊
Zaporozhye Medical Journal
Zaporozhye Medical Journal MEDICINE, GENERAL & INTERNAL-
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审稿时长
8 weeks
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