Genetically manipulated mice models as research tool

Genetically modified mouse models have emerged as an excellent approach to provide insight into gene regulation, development, pathogenesis, and the treatment of disease.Transgenic models are the biological tools that aid target discovery, validation, and production of therapeutic proteins. Despite several theoretical and technical challenges in generation of knockout models, transgenic technology holds great potential in many fields including medicine, industry. This short review covers briefly the methods used to produce transgenic mice and the importance of these genetically modified animals in biomedical research.