改进Knoevenagel缩合法合成氰基丙烯酸酯及其抗癌活性

IF 1.1 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of the Mexican Chemical Society Pub Date : 2023-01-09 DOI:10.29356/jmcs.v67i1.1835

Hari Babu Bolikolla, Santha Kumari Merugu

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引用次数: 0

摘要

DIPEAc (diisopropylethylammonium acetate)你也被用来作为催化剂的in the Knoevenagel condensation of aldehydes and ethyl cyanoacetate to produce cyanoacrylate with high yields。该反应的主要特点是反应时间短、底物范围广、不同功能组的可行性、易于操作和产量高，提供环境效益。此外，还对合成的氰基丙烯酸酯衍生物系列对A549、HT-29和HepG2细胞系的抗癌活性进行了测试。摘要。以二异丙基乙酸乙酯铵(DIPEAc)为催化剂，将醛与氰酸乙酸乙酯进行Knoevenagel缩合反应，高产产氰酸丙烯酸酯。该应用的一些特点是反应时间短，可以在广泛的基材上进行，耐多个官能团，反应工作简单，产量高，与环境兼容。在本研究中，我们评估了两种不同的方法，一种是在实验室中进行的，另一种是在实验室中进行的。

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Improved Knoevenagel Condensation Protocol for the Synthesis of Cyanoacrylates and their Anticancer Activity

DIPEAc (diisopropylethylammonium acetate) has been used as a catalyst in the Knoevenagel condensation of aldehydes and ethyl cyanoacetate to produce cyanoacrylate with high yields. The reaction's key characteristics are a shorter reaction time, a large substrate scope, the viability of different functional groups, ease of work-up, and high yields, which provide environmental benefits. Furthermore, the anticancer activity of the synthesized series of cyanoacrylate derivatives was tested against A549, HT-29, and HepG2 cell lines. Resumen. El aetato de diisopropiletilamonio (DIPEAc) se empleó como catalizador en la reacción de condensación de Knoevenagel emplenado aldehídos y cianoacetato de etilo para producir cianoacrilatos en reindimientos elevados. Algunas características de esta aplicación es el que requiere tiempos cortos de reacción, se puede practicar en una amplia gama de sustratos, tolera varios grupos funcionales, el trabajo de la reacción es sencillo y tiene elvados rendimientos, lo que es compatible con el medio ambiente. Los productos obtenidos fueron probados con las líneas celulares A549, HT-29 y HepG2.

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来源期刊

Journal of the Mexican Chemical Society 化学-化学综合

CiteScore

2.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of the Mexican Chemical Society (J. Mex. Chem. Soc.) is a scientific, blind, peer reviewed, and open access, free of charge publication that covers all areas of chemistry and its sub-disciplines (i.e. medicinal chemistry, natural products, electrochemistry, material science, computational chemistry, organic chemistry, bionirganic chemistry, etc). It is devoted to facilitating the worldwide advancement of our understanding of chemistry. It will primarily publish original contributions of research in all branches of the theory and practice of chemistry in its broadest context as well as critical reviews in active areas of chemical research where the author has published significant contribution. The J. Mex. Chem. Soc. is a quarterly publication which language of submission and publication is English. To be suitable for publication in J. Mex. Chem. Soc., manuscripts must describe novel aspects of chemistry, high quality of results and discussion an excellent bibliographic support, and contribute to the development of the field. Routine or incremental work are not suitable for publication in J. Mex. Chem. Soc. Authors are encouraged to send contributions in electronic form. Our online submission system guides you stepwise through the process of entering your article details and uploading your files.