Anti-aging effect of magnesium lithospermate β from Salvia miltiorrhiza Bunge on skin

Magnesium lithospermate B (MLB, also called salvianolic acid B), one of the hydrophilic phenolic compounds of Salvia miltiorrhiza Bunge has been reported to possess numerous health benefits, but a role for MLB in the prevention of skin aging has not been fully explored. In a recent publication, we reported that the skin anti-aging action of MLB depends on its ability to suppress collagen degradation via its anti-oxidant activity, and subsequently, to increase the expressions of type I and III collagen genes through PPARb/d activation. For this research highlight, we describe the salient findings from our recent study on the anti-wrinkle effect of MLB and the molecular mechanism underlying its skin anti-aging action.