188例成年I、II、IIIA期霍金淋巴瘤患者ABVD加次全淋巴结放疗3个疗程后的远期疗效

IF 3 Q2 Medicine

Clinical Medicine Insights-Blood Disorders Pub Date : 2008-01-01 DOI:10.4137/CMBD.S357

P. Brice, M. André, P. Franchi-Rezgui, I. Biasoli, C. Hennequin

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引用次数: 0

摘要

在霍奇金淋巴瘤(HL)患者中，观察到高治愈率的结果持续改善，但治疗引起的晚期效应增加。我们报告了1985- 1994年期间188例(I期至IIIA期)患者接受abvd样化疗和次全淋巴结放疗的长期结果。10年总生存率为88%，未观察到继发性白血病。主要的长期毒性是心脏，主要与部分缓解患者的纵隔剂量45格雷有关。新的策略旨在减少化疗诱导的完全缓解后30 gray的纵隔剂量。

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Long Term Results after 3 Courses of ABVD plus Subtotal Nodal Radiotherapy in 188 Adult Patients with Stage I, II and IIIA Hodgin Lymphoma

In patients with Hodgkin lymphoma (HL) a continued improvement in outcome with a high cure rate is observed but with an increased treatment-induced late effects. We report the long-term results from 188 (stage I to IIIA) patients treated during the period 1985-94 with 3 courses of ABVD-like chemotherapy and subtotal nodal radiotherapy. 10 year overall survival is of 88% and no secondary leukaemia was observed. The main long term toxicity was cardiac, mainly related to a mediastinal dose of 45 Grays in patients with partial remission. New strategies are aiming to reduce the mediastinal dose at 30 Grays after chemotherapy-induced complete remission.

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来源期刊

Clinical Medicine Insights-Blood Disorders HEMATOLOGY-

CiteScore

3.70

自引率

0.00%

发文量

审稿时长

8 weeks