腹膜透析液中对甲酚的检测

2019 IEEE Conference of Russian Young Researchers in Electrical and Electronic Engineering (EIConRus) Pub Date : 2019-01-01 DOI:10.1109/EICONRUS.2019.8657038

B. M. Putrya, N. Zhilo, V. Grinval’d, N. A. Bazaev

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引用次数: 0

摘要

对甲酚是由4-羟基苯基乙酸在小肠内合成的一种代谢物。在代谢过程中，这种底物被肾脏过滤，并随尿液离开机体。在慢性肾脏病的情况下，对甲酚在体液中积聚，必须通过透析的方式去除。为了估计对甲酚清除率和透析方法的效率，必须测量和控制该底物的浓度。探讨了循环伏安法检测和消除对甲酚的可能性。结果表明，石墨电极可用于对甲酚的检测和评价。饱和Ag/ agcl电极在650 mV电位附近观察到对甲酚氧化峰。研究了对甲酚浓度对氧化峰高度的影响。建议的方法可用于透析液再生效率的控制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Detection of P-Cresol in Solution for Peritoneal Dialysis

p-Cresol is a metabolite which is synthesized by be intestinal bacteria in the small intestine from 4-hydroxyphenylacetate acid. During metabolism this substrate is filtered by kidneys and leaves the organism with urine. In case of chronic kidney decease p-cresol accumulates in body fluids and has to be removed by means of dialysis. To estimate p-cresol clearance and the efficiency of dialysis methods concentration of this substrate has to be measured and controlled. The possibility of p-cresol detection and elimination by means of cyclic voltammetry method was investigated. It is shown that graphite electrodes can be used for p-cresol’s detection and evaluation. p-Cresol oxidation peak was observed near potential 650 mV against saturated Ag/AgCl-electrode. Influence of p-cresol concentration on oxidation peak height was also investigated. Suggested technique can be used for dialysate regeneration efficiency control.

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来源期刊

2019 IEEE Conference of Russian Young Researchers in Electrical and Electronic Engineering (EIConRus)

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