有自杀意念的重度抑郁症患者与无自杀意念的患者相比，血浆载脂蛋白aiv下调

IF 0.5 4区生物学 Q4 BIOCHEMICAL RESEARCH METHODS

Current Proteomics Pub Date : 2021-11-04 DOI:10.2174/1570164618666211104151005

Boby Mathew, K. Srinivasan, Johnson Pradeep, Tinku Thoma, A. Mandal

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引用次数: 0

摘要

外周生物标志物的识别可能有助于识别高危自杀患者，并可能有助于有效的早期干预。在本研究中，我们扩展了之前多维蛋白质组学研究的发现，通过检测有或没有自杀意念的重度抑郁症患者的血浆载脂蛋白- aiv水平，并与年龄和性别匹配的对照组进行比较。使用质谱平台，我们用同位素标记肽为基础的定量蛋白质组学方法，定量了有或无自杀意念的重度抑郁症患者血浆载脂蛋白aiv水平，并与匹配的对照组进行了比较。使用同位素标记肽的靶向定量蛋白质组学方法显示，有自杀意念的抑郁症患者血浆载脂蛋白aiv明显下调1.45 (CI: 1.11-1.90)，而没有自杀意念的抑郁症患者血浆载脂蛋白aiv明显下调0.88 (CI: 0.77-1.003)。这些发现将我们早期观察到的自杀未遂患者血浆载脂蛋白aiv下调扩展到有自杀意念的抑郁症患者。两项蛋白质组学研究均观察到血浆载脂蛋白- aiv的持续下调，这表明载脂蛋白- aiv可能是一种基于血浆的自杀行为生物标志物。

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Plasma Apolipoprotein-AIV Downregulated in Patients with Major Depressive Disorder having Suicidal Ideation Compared to those without Suicidal Ideation

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Plasma Apolipoprotein-AIV Downregulated in Patients with Major Depressive Disorder having Suicidal Ideation Compared to those without Suicidal Ideation

Identification of a peripheral biological marker might aid in identifying patients at high risk of attempting suicide and might help in effective early intervention. In the present study, we extend the findings of our previous multidimensional proteomics study by examining the levels of plasma Apolipoprotein-AIV in patients diagnosed with major depression with and without suicidal ideation compared to age and gender-matched controls. Using the mass spectrometry platform, we quantified the levels of plasma Apolipoprotein-AIV in patients with major depressive disorder with and without suicidal ideation compared to matched controls with isotope-labelled peptides-based quantitative proteomics approach. The targeted quantitative proteomics approach with isotope-labelled peptides showed that plasma Apolipoprotein-AIV was significantly downregulated in depressed patients having suicidal ideation 1.45 (CI:1.11–1.90) compared to those without suicidal ideation 0.88 (CI:0.77–1.003). These findings extend our earlier observation of downregulation of plasma Apolipoprotein-AIV in patients with suicidal attempts to depressed patients with suicidal ideation. The consistent downregulation of plasma Apolipoprotein-AIV observed in both the proteomics studies suggests Apolipoprotein-AIV might be a plasma-based biomarker for suicidal behaviour.

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来源期刊

Current Proteomics BIOCHEMICAL RESEARCH METHODS-BIOCHEMISTRY & MOLECULAR BIOLOGY

CiteScore

1.60

自引率

0.00%

发文量

审稿时长

>0 weeks

期刊介绍： Research in the emerging field of proteomics is growing at an extremely rapid rate. The principal aim of Current Proteomics is to publish well-timed in-depth/mini review articles in this fast-expanding area on topics relevant and significant to the development of proteomics. Current Proteomics is an essential journal for everyone involved in proteomics and related fields in both academia and industry. Current Proteomics publishes in-depth/mini review articles in all aspects of the fast-expanding field of proteomics. All areas of proteomics are covered together with the methodology, software, databases, technological advances and applications of proteomics, including functional proteomics. Diverse technologies covered include but are not limited to: Protein separation and characterization techniques 2-D gel electrophoresis and image analysis Techniques for protein expression profiling including mass spectrometry-based methods and algorithms for correlative database searching Determination of co-translational and post- translational modification of proteins Protein/peptide microarrays Biomolecular interaction analysis Analysis of protein complexes Yeast two-hybrid projects Protein-protein interaction (protein interactome) pathways and cell signaling networks Systems biology Proteome informatics (bioinformatics) Knowledge integration and management tools High-throughput protein structural studies (using mass spectrometry, nuclear magnetic resonance and X-ray crystallography) High-throughput computational methods for protein 3-D structure as well as function determination Robotics, nanotechnology, and microfluidics.