螺旋藻(Arthrospira platensis)对邻苯二甲酸二(2-乙基己基)致Wistar大鼠毒性的减弱作用

IF 3.6 4区环境科学与生态学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Environmental Pollutants and Bioavailability Pub Date : 2023-04-17 DOI:10.1080/26395940.2023.2197154

Munira Abdullah Rashed Alqahtani, P. Virk, D. Fouad

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Attenuating Effect of Spirulina (Arthrospira platensis) against Di (2-ethylhexyl) Phthalate Induced Toxicity in Wistar Rat

ABSTRACT Di(2-ethylhexyl) phthalate (DEHP) is an extensively used plasticizer and being non-covalently bound to plastics it leaches out into the environment. This addresses a grave concern on its potential human exposure and subsequent deleterious effects. The ameliorative potential of Spirulina (Arthrospira platensis) against DEHP-induced toxicity was assessed in rats. Group I was control. Group II and III, were exposed to a low dose of DEHP (125 mg/kg), and Group IV and V were exposed to a high dose of DEHP (250 mg/kg). Group III and V were treated with spirulina orally (1000 mg/Kg) for 3 weeks. Exposure to DEHP elicited marked oxidative stress and associated DNA damage in a dose-dependent manner. The hepatic expression of p53 was also significantly suppressed. Liver and kidney function tests showed marked alterations. Treatment with spirulina efficaciously reversed the adverse effects. Thus, these findings offer a nutritional intervention of spirulina to combat the environmental exposure to plasticizers. GRAPHICAL ABSTRACT

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来源期刊

Environmental Pollutants and Bioavailability Chemical Engineering-Chemical Health and Safety

CiteScore

4.30

自引率

3.00%

发文量

审稿时长

13 weeks

期刊介绍： Environmental Pollutants & Bioavailability is a peer-reviewed open access forum for insights on the chemical aspects of pollutants in the environment and biota, and their impacts on the uptake of the substances by living organisms. Topics include the occurrence, distribution, transport, transformation, transfer, fate, and effects of environmental pollutants, as well as their impact on living organisms. Substances of interests include heavy metals, persistent organic pollutants, and emerging contaminants, such as engineered nanomaterials, as well as pharmaceuticals and personal-care products as pollutants.