手足综合征与皮肤Reactıons Followıng Fırst化疗剂量

M. Yıldırım, B. Karabulut
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引用次数: 0

摘要

我科收治1例63岁女性IIIA期乳腺癌患者,采用5氟尿嘧啶、表柔比星、环磷酰胺联合化疗。临床和精神检查没有发现任何疾病的迹象,体格检查也不明显。患者接受5氟尿嘧啶720 mg/ m2,表柔比星145mg/ m2,环磷酰胺720 mg/ m2,第1天输注,每3周重复一次。在第1天开始治疗之前,静脉注射地塞米松4mg和格拉司琼3mg,以预防恶心和呕吐。同样的止吐治疗在第2天静脉注射,第3天和第4天口服。第一个治疗周期平安无事。在给药第2个周期4天后,患者因手足综合征(HFS)入院,伴有手部指甲变化(色素沉着)和躯干斑疹丘疹(图1、2、3、4和5)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hand- Foot Syndrome And Cutaneous Reactıons Followıng Fırst Dose Of Chemotherapy
A 63-year-old female with stage IIIA breast cancer was treated in our department with adjuan chemotherapy containing 5fluoruracil,epirubicine and cyclophosphamide. Clinical and anamnetic findings revealed no signs of any disorder and physical examination was unremarkable. The patient received, 5fluoruracil 720 mg/m 2 , epirubicine 145mg/m and cyclophosphamide 720 mg/m administered as a infusion on day one, repeated every three weeks. Treatment given on day 1 was preceded by dexametasone 4 mg i.v. and granisetron 3 mg i.v. for the prophylaxis of nausea and vomiting. The same anti-emetic treatment was repeated i.v.on day 2 and orally on days 3 and 4. The first treatment cycle was uneventful. Four days after administration of the second cycle the patient was admitted to our clinic with hand-foot syndrome(HFS), associated with nail changes on hand (hyperpigmentation) and maculopapuler eruptions on the trunk(Figure 1,2,3,4 and 5).
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