德米霍夫现象。在N.V. Sklifosovsky研究所(1960-1986)。同源器官移植的范式转变:从克服生物不相容到人工免疫耐受(1960-1970)

S. Glyantsev
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引用次数: 0

摘要

对1968-1969年期间关于实验和临床移植的文献的分析表明,1960 - 1970年期间,世界移植在同型器官移植领域发生了范式变化:不是通过使用生物和生理方法来影响器官来克服供体器官与受体身体之间的不相容,这是德米霍夫副总统多年来一直在处理的;外科医生和科学家,首先在国外,然后在苏联开始开发和应用人工免疫耐受性的创造,通过使用各种物理,化学和生物方法来影响接受者的身体。范式的转变对包括重要器官在内的器官移植技术在临床中的应用以及临床移植学的进一步发展产生了重大影响。第一例心脏移植于1968年,第一例肺移植于1963-1970年。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
PHENOMENON OF DEMIKHOV. At N.V. Sklifosovsky Institute (1960–1986). Paradigm shift in homologous organ transplantation: from overcoming biological incompatibility to artificial immunological tolerance (1960–1970)
The analysis of literature on experimental and clinical transplantation for the period of the 1968–1969 demonstrated that in the period from 1960 to 1970 the world transplantation saw a paradigm change in the field of homoorgan transplant: instead of overcoming the incompatibility between the donor organ and the recipient's body by using biological and physiological methods to influence the organ, which V.P. Demikhov had been dealing with for many years; surgeons and scientists, first abroad, and then in the USSR started developing and applying the creation of artificial immunological tolerance by using various physical, chemical and biological methods to impact recipient's body. The change of paradigms significantly influenced the implementation of organ transplantation techniques in clinic, including those of vital organs, and the further development of clinical transplantology. The data on the first heart transplants in 1968 and lung transplants in 1963–1970 have been presented.
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