【痛风的病因、机制和可能的治疗靶点】。

Therapeutische Umschau und medizinische Bibliographie. Revue therapeutique et bibliographie medicale Pub Date : 2016-03-23 DOI:10.1024/0040-5930/a000771

T. Manigold

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引用次数: 0

摘要

痛风是世界上最常见的关节炎，在工业化国家的患病率越来越高，并产生了巨大的社会经济后果。在过去的十年中，关于导致关节炎的病理机制的知识大大增加了。不断有新的治疗方法和物质出现在地平线上。本文综述了临床表现、诊断和目前的治疗。本文对NLRP3炎性体激活和il -1分泌的病理机制进行了详细的综述。最后讨论了新的治疗靶点和药物的选择。

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[Causes, mechanisms and possible therapeutic targets of gout].

Gout is the most frequent arthritis worldwide with increasing prevalence in industrialized countries and massive socioeconomic consequences. The knowledge regarding the pathomechanisms which lead to arthritis has substantially increased during the last decade. Consistently, new therapeutic approaches and substances appear at the horizon. This review covers aspects of clinical presentation, diagnosis and current treatment. The pathomechanisms leading to NLRP3 inflammasome activation and IL-1beta secretion are reviewed in detail. Finally, selected new therapeutic targets and substances are discussed.

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Therapeutische Umschau und medizinische Bibliographie. Revue therapeutique et bibliographie medicale

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