以Wang树脂为固体载体的Kalata B2环聚糖(GLPVCGETCFGGTCNTPGCSCTWPICTRD)的合成与表征

药物化学期刊(英文) Pub Date : 2020-04-24 DOI:10.4236/ojmc.2020.102004

Verma Deepshikha, P. Rajasekharan

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引用次数: 0

摘要

采用固相多肽合成法合成了Kalata B2环肽，并用制备型高效液相色谱法对产物进行了纯化。Kalata B2序列为GLPVCGETCFGGTCNTPGCSCTWPICTRD, m/z m + H质量为2955.53。该化合物首次从茜草科植物亲和叶提取物中分离得到。通过UPLC/MS、LC/MS、CD、1HNMR和IR对Kalata B2的合成进行了表征。

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Synthesis and Characterization of Kalata B2 Cyclotide (GLPVCGETCFGGTCNTPGCSCTWPICTRD) on Wang Resin, as Solid Support

With the help of the solid phase peptide synthesizing method, we synthesized Kalata B2 cyclotide and the final product was purified by preparative HPLC. The sequence of Kalata B2 is GLPVCGETCFGGTCNTPGCSCTWPICTRD and its m/z M + H mass is 2955.53. It had been first isolated from Oldenlandia affinis plant leaves extract which belongs to Rubiaceae family. The synthesis of Kalata B2 has been characterized through UPLC/MS, LC/MS, CD, 1HNMR, and IR.

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药物化学期刊(英文)

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