A rare solitary neurofibroma of the philtrum of upper lip

Neurofibromas are relatively common benign tumors usually originating from peripheral nerves. Multiple neurofibromas are seen as part of von Recklinghausen`s neurofibromatosis. But, solitary neurofibroma is particularly a rarity in the Head and Neck. A 69-year-old woman was referred due to a complaint of swelling in the philtrum of upper lip with no other symptoms. Due to the suspicion of a tumor in the lip, MRI was taken and hemangioma was considered. A diagnosis of solitary neurofibroma was made through a surgical specimen by excisioned intra-orally by general anesthesia, from the lesion by histological examination and immunohistochemistry for the S-100 protein. And 4-year follow-up, she was free of symptoms and signs of recurrence were not detected.