{"title":"脊髓小脑共济失调 2 型的分子机制和治疗方法。","authors":"Polina A Egorova, Ilya B Bezprozvanny","doi":"10.1007/s13311-019-00777-6","DOIUrl":null,"url":null,"abstract":"<p><p>The effective therapeutic treatment and the disease-modifying therapy for spinocerebellar ataxia type 2 (SCA2) (a progressive hereditary disease caused by an expansion of polyglutamine in the ataxin-2 protein) is not available yet. At present, only symptomatic treatment and methods of palliative care are prescribed to the patients. Many attempts were made to study the physiological, molecular, and biochemical changes in SCA2 patients and in a variety of the model systems to find new therapeutic targets for SCA2 treatment. A better understanding of the uncovered molecular mechanisms of the disease allowed the scientific community to develop strategies of potential therapy and helped to create some promising therapeutic approaches for SCA2 treatment. Recent progress in this field will be discussed in this review article.</p>","PeriodicalId":46187,"journal":{"name":"International Journal of Security and Its Applications","volume":"10 1","pages":"1050-1073"},"PeriodicalIF":0.0000,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985344/pdf/","citationCount":"0","resultStr":"{\"title\":\"Molecular Mechanisms and Therapeutics for Spinocerebellar Ataxia Type 2.\",\"authors\":\"Polina A Egorova, Ilya B Bezprozvanny\",\"doi\":\"10.1007/s13311-019-00777-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The effective therapeutic treatment and the disease-modifying therapy for spinocerebellar ataxia type 2 (SCA2) (a progressive hereditary disease caused by an expansion of polyglutamine in the ataxin-2 protein) is not available yet. At present, only symptomatic treatment and methods of palliative care are prescribed to the patients. Many attempts were made to study the physiological, molecular, and biochemical changes in SCA2 patients and in a variety of the model systems to find new therapeutic targets for SCA2 treatment. A better understanding of the uncovered molecular mechanisms of the disease allowed the scientific community to develop strategies of potential therapy and helped to create some promising therapeutic approaches for SCA2 treatment. Recent progress in this field will be discussed in this review article.</p>\",\"PeriodicalId\":46187,\"journal\":{\"name\":\"International Journal of Security and Its Applications\",\"volume\":\"10 1\",\"pages\":\"1050-1073\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985344/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Security and Its Applications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s13311-019-00777-6\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Security and Its Applications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s13311-019-00777-6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Molecular Mechanisms and Therapeutics for Spinocerebellar Ataxia Type 2.
The effective therapeutic treatment and the disease-modifying therapy for spinocerebellar ataxia type 2 (SCA2) (a progressive hereditary disease caused by an expansion of polyglutamine in the ataxin-2 protein) is not available yet. At present, only symptomatic treatment and methods of palliative care are prescribed to the patients. Many attempts were made to study the physiological, molecular, and biochemical changes in SCA2 patients and in a variety of the model systems to find new therapeutic targets for SCA2 treatment. A better understanding of the uncovered molecular mechanisms of the disease allowed the scientific community to develop strategies of potential therapy and helped to create some promising therapeutic approaches for SCA2 treatment. Recent progress in this field will be discussed in this review article.
期刊介绍：
IJSIA aims to facilitate and support research related to security technology and its applications. Our Journal provides a chance for academic and industry professionals to discuss recent progress in the area of security technology and its applications. Journal Topics: -Access Control -Ad Hoc & Sensor Network Security -Applied Cryptography -Authentication and Non-repudiation -Cryptographic Protocols -Denial of Service -E-Commerce Security -Identity and Trust Management -Information Hiding -Insider Threats and Countermeasures -Intrusion Detection & Prevention -Network & Wireless Security -Peer-to-Peer Security -Privacy and Anonymity -Secure installation, generation and operation -Security Analysis Methodologies -Security assurance -Security in Software Outsourcing -Security products or systems -Security technology -Systems and Data Security
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