马齿苋苷- A、亚补酸和山奈酚对内皮素-1所致大鼠脑缺血的抗氧化和神经保护作用

Q2 Pharmacology, Toxicology and Pharmaceutics

journal of applied pharmaceutical science Pub Date : 2023-01-01 DOI:10.7324/japs.2023.153365

Ashutosh Ghosh, Nasima Khanam, D. Nath

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引用次数: 0

摘要

本研究旨在探讨马齿苋苷a、亚洲积雪草酸和山奈酚作为抗氧化剂对内皮素-1 (ET-1)诱导的大鼠局灶性脑缺血的神经保护作用。口服马齿苋苷a (50 mg/kg)、亚洲酸(50 mg/kg)和山奈酚(50 mg/kg)与载药组相比，梗死面积分别显著降低至31.8%±1.30%、32.3%±1.25%和34.06%±1.30%。神经功能缺损明显减轻，小胶质细胞和星形胶质细胞的神经病理状况也得到改善。钙水平和丙二醛水平显著升高，抗氧化酶超氧化物歧化酶、过氧化氢酶和还原性谷胱甘肽水平显著降低(p < 0.01)。考虑到功效水平，Bacoside-A被发现是三种植物化学物质中最有效的神经保护抗氧化剂。

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Evaluation on antioxidative and neuroprotective activity of bacoside- A, Asiatic acid and kaempferol in endothelin-1 induced cerebral ischemia in rat

The framework of the present study was mapped out to evaluate the neuroprotective efficacy of bacoside-A, asiatic acid, and kaempferol as antioxidants in the endothelin-1 (ET-1) induced focal cerebral ischemic brain of rats. Oral administration of bacoside-A (50 mg/kg), asiatic acid (50 mg/kg), and kaempferol (50 mg/kg) significantly reduced the infarct volume to 31.8% ± 1.30%, 32.3% ± 1.25%, and 34.06% ± 1.30%, respectively, compared to the vehicle– treated ischemic (I/R) group. The neurological deficit was significantly reduced and the neuropathological condition of microglia and astrocytes were also improved. Significant increase of calcium levels and malondialdehyde and reduction ( p < 0.01) at the levels of antioxidative enzymes superoxide dismutase, catalase and reduced glutathione were observed. Considering the level of efficacy, Bacoside-A was found to be the most potent neuroprotective antioxidant among three phytochemicals.

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来源期刊

journal of applied pharmaceutical science Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

2.20

自引率

0.00%

发文量

224

期刊介绍： Journal of Applied Pharmaceutical Science (JAPS) is a monthly, international, open access, journal dedicated to various disciplines of pharmaceutical and allied sciences. JAPS publishes manuscripts (Original research and review articles Mini-reviews, Short communication) on original work, either experimental or theoretical in the following areas; Pharmaceutics & Biopharmaceutics Novel & Targeted Drug Delivery Nanotechnology & Nanomedicine Pharmaceutical Chemistry Pharmacognosy & Ethnobotany Phytochemistry Pharmacology & Toxicology Pharmaceutical Biotechnology & Microbiology Pharmacy practice & Hospital Pharmacy Pharmacogenomics Pharmacovigilance Natural Product Research Drug Regulatory Affairs Case Study & Full clinical trials Biomaterials & Bioactive polymers Analytical Chemistry Physical Pharmacy.