流动相反相高效液相色谱法测定他汀类药物的含量

Izvestiya of Saratov University. New Series. Series: Chemistry. Biology. Ecology Pub Date : 2022-12-15 DOI:10.18500/1816-9775-2022-22-4-364-372

Angelina A. Kutina, E. G. Sumina, N. Yurasov, V. Z. Uglanova

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引用次数: 0

摘要

采用反相高效液相色谱法(HPLC)研究了阿托伐他汀、瑞舒伐他汀和辛伐他汀在流动相主要修饰剂洗脱强度和缓冲溶液存在下的色谱行为。找到了最佳修饰条件，并将其应用于阿托伐他汀、利普利马和郁金香等制剂中他汀类药物的含量测定。Sr值为0.03。相对测定误差不超过7%。

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Determination of statins by reverse-phase HPLC in mobile phases with different modification options

The chromatographic behavior of atorvastatin, rosuvastatin and simvastatin in the presence of the main modifiers of the mobile phase: elution strength and buffer solution, has been studied by means of the reverse-phase high-performance liquid chromatography (HPLC) method. Optimal modification conditions have been found and their application for the determination of statins under study in the pharmaceutical preparations Atorvastatin-OBL, Liprimar and Tulip has been shown. The Sr value is 0.03. The relative determination error does not exceed 7%.

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Izvestiya of Saratov University. New Series. Series: Chemistry. Biology. Ecology

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