n6 -甲基腺苷修饰的RNA作为一种分子胶，在植物中驱动液-液相分离

IF 2.8 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Plant Signaling & Behavior Pub Date : 2022-05-27 DOI:10.1080/15592324.2022.2079308

H. Lee, Jiwoo Kim, P. Seo

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引用次数: 2

摘要

类液体凝聚物是由多价内在无序的蛋白质和RNA分子组成的。我们在这里证明了n6 -甲基腺苷(m6A)修饰的RNA在建立各种植物细胞凝聚体中广泛存在。几种m6a解读蛋白含有推测的朊病毒样结构域，在拟南芥中，ect2/3/4突变体显示出关键核和细胞质凝聚物的形成减少。

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N6-methyladenosine–modified RNA acts as a molecular glue that drives liquid–liquid phase separation in plants

ABSTRACT Liquid-like condensates are organized by multivalent intrinsically disordered proteins and RNA molecules. We here demonstrate that N6-methyladenosine (m6A)-modified RNA is widespread in establishing diverse plant cell condensates. Several m6A-reader proteins contain putative prion-like domains, and the ect2/3/4 mutant exhibited reduced formation of key nuclear and cytoplasmic condensates in Arabidopsis.

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来源期刊

Plant Signaling & Behavior Agricultural and Biological Sciences-Plant Science

CiteScore

6.00

自引率

3.40%

发文量

111

期刊介绍： Plant Signaling & Behavior, a multidisciplinary peer-reviewed journal published monthly online, publishes original research articles and reviews covering the latest aspects of signal perception and transduction, integrative plant physiology, and information acquisition and processing.