{"title":"EOCS-MCP 2008研讨会组织","authors":"Longbing Cao, Ruwei Dai, V. Gorodetski","doi":"10.1109/COMPSAC.2008.262","DOIUrl":null,"url":null,"abstract":"A process for preparing a 2-thio-2-substituted-alkanoic acid derivative represented by the formula (I) (I) wherein A, R, R3 and R4 are as defined hereinafter, which comprises condensing an aldehyde compound of the formula (V) A-CHO (V) wherein A is as defined hereinafter, with a haloform of the formula CHX3 wherein X is as defined hereinafter and a mercaptan compound of the formula (IV) R3SH (IV) wherein R3 is as defined hereinafter, in the presence of a base to produce a 2-(arylthio or alkylthio)-2-substituted-acetic acid of the formula (III) (III) wherein A and R3 are as defined hereinafter, and reacting the resulting 2-(arylthio or alkylthio)-2-substituted-acetic acid of the formula (III) with an alkylating agent represented by the formula (II) RZ (II) wherein R and Z are as defined hereinafter, in the presence of at least 2 mols of a base per mol of the 2-(arylthio or alkylthio)-2-substituted-acetic acid, to form the compound of the formula (I) wherein R4 represents a hydrogen atom and, optionally, converting the resulting compound to the compound of the formula (I) wherein R4 represents an alkyl group by esterification.","PeriodicalId":74502,"journal":{"name":"Proceedings : Annual International Computer Software and Applications Conference. COMPSAC","volume":"511 1","pages":"860-861"},"PeriodicalIF":0.0000,"publicationDate":"2008-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"EOCS-MCP 2008 Workshop Organization\",\"authors\":\"Longbing Cao, Ruwei Dai, V. Gorodetski\",\"doi\":\"10.1109/COMPSAC.2008.262\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A process for preparing a 2-thio-2-substituted-alkanoic acid derivative represented by the formula (I) (I) wherein A, R, R3 and R4 are as defined hereinafter, which comprises condensing an aldehyde compound of the formula (V) A-CHO (V) wherein A is as defined hereinafter, with a haloform of the formula CHX3 wherein X is as defined hereinafter and a mercaptan compound of the formula (IV) R3SH (IV) wherein R3 is as defined hereinafter, in the presence of a base to produce a 2-(arylthio or alkylthio)-2-substituted-acetic acid of the formula (III) (III) wherein A and R3 are as defined hereinafter, and reacting the resulting 2-(arylthio or alkylthio)-2-substituted-acetic acid of the formula (III) with an alkylating agent represented by the formula (II) RZ (II) wherein R and Z are as defined hereinafter, in the presence of at least 2 mols of a base per mol of the 2-(arylthio or alkylthio)-2-substituted-acetic acid, to form the compound of the formula (I) wherein R4 represents a hydrogen atom and, optionally, converting the resulting compound to the compound of the formula (I) wherein R4 represents an alkyl group by esterification.\",\"PeriodicalId\":74502,\"journal\":{\"name\":\"Proceedings : Annual International Computer Software and Applications Conference. COMPSAC\",\"volume\":\"511 1\",\"pages\":\"860-861\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2008-07-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings : Annual International Computer Software and Applications Conference. COMPSAC\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/COMPSAC.2008.262\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings : Annual International Computer Software and Applications Conference. COMPSAC","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/COMPSAC.2008.262","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A process for preparing a 2-thio-2-substituted-alkanoic acid derivative represented by the formula (I) (I) wherein A, R, R3 and R4 are as defined hereinafter, which comprises condensing an aldehyde compound of the formula (V) A-CHO (V) wherein A is as defined hereinafter, with a haloform of the formula CHX3 wherein X is as defined hereinafter and a mercaptan compound of the formula (IV) R3SH (IV) wherein R3 is as defined hereinafter, in the presence of a base to produce a 2-(arylthio or alkylthio)-2-substituted-acetic acid of the formula (III) (III) wherein A and R3 are as defined hereinafter, and reacting the resulting 2-(arylthio or alkylthio)-2-substituted-acetic acid of the formula (III) with an alkylating agent represented by the formula (II) RZ (II) wherein R and Z are as defined hereinafter, in the presence of at least 2 mols of a base per mol of the 2-(arylthio or alkylthio)-2-substituted-acetic acid, to form the compound of the formula (I) wherein R4 represents a hydrogen atom and, optionally, converting the resulting compound to the compound of the formula (I) wherein R4 represents an alkyl group by esterification.
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