核黄素和氰钴胺对环磷酰胺肺毒性大鼠肺保护作用的研究

Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) Pub Date : 2023-06-16 DOI:10.31351/vol32iss1pp100-106

Waleed K. Ghanim, Muhsin S. G. Al-Moziel, Hussein M. Abood

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引用次数: 0

摘要

环磷酰胺(CP)是一种细胞毒性烷基化剂，它的使用伴随着不同的副作用，包括肺毒性。维生素B2和维生素B12有保护肺部的作用。本研究旨在评价两种维生素对环磷酰胺所致肺毒性的肺保护作用。将70只健康成年白化雄性和雌性大鼠分为7组，每组10只，治疗7天。第8天，处死8只大鼠，取血清测定谷胱甘肽和总抗氧化能力，提取肺进行免疫组化研究;与对照组相比，两种维生素显著(P<0.05)提高了谷胱甘肽和总抗氧化能力，与仅环磷酰胺组相比，改善了免疫组织化学变化

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Study The Lung-Protective Effects of Riboflavin and Cyanocobalamin Against Lung Toxicity-Induced by Cyclophosphamide in Rats

Cyclophosphamide (CP) is a cytotoxic alkylating agent it's used associated with different side effects including lung toxicity. Vitamin B2 and vitamin B12 have lung-protective effects. This study was designed to evaluate lung-protective effects of both vitamins against lung toxicity induced by cyclophosphamide. seventy healthy adult albino male and female rats divided into seven groups each group containing ten rats were used in the present study and treated for seven days. On day eight rats were sacrificed and serum was obtained for glutathione and total antioxidant capacity measurement and lung extracted for immunohistochemical study; both vitamins significantly (P<0.05) increased glutathione and total antioxidant capacity in comparison with group two and improve immunohistochemical changes in comparison with the group treated by cyclophosphamide only

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Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512)

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